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Bezlotoxumab during the first episode of Clostridioides difficile infection in patients at high risk of recurrence
PurposeTo describe a cohort with a high risk of recurrence who received bezlotoxumab during the first episode of Clostridioides difficile infection...
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Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand: a randomized controlled trial
BackgroundThe left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control...
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Incremental costs of hospital-acquired infections in COVID-19 patients in an adult intensive care unit of a tertiary hospital from a low-resource setting
BackgroundHospital-acquired infections (HAIs) are a global public health problem and put patients at risk of complications, including death. HAIs...
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Proteomic characteristics of the treatment trajectory of patients with COVID-19
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has prompted global concern due to its profound impact on public health and the economy. Effective...
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Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey
Evaluating trends in antibiotic resistance is a requisite. The study aimed to analyze the profile of multidrug-resistant organisms (MDROs) among...
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Clinical interest of molecular study in cases of isolated midline craniosynostosis
In some cases of infants with apparently isolated single-suture synostosis, an underlying variant can be found. We aimed to determine the molecular...
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The use of multi-pronged screening strategy to understand the epidemiology of carbapenemase-producing Enterobacteriaceae in Hong Kong: transition from epidemic to endemic setting
A multi-pronged carbapenemase-producing Enterobacteriaceae (CPE) screening strategy was implemented in Hong Kong West healthcare network. Of 199,192...
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The global dissemination of hospital clones of Enterococcus faecium
BackgroundThe hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant...
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Epidemiology of carbapenem-resistant and carbapenemase-producing Enterobacterales in the Netherlands 2017–2019
BackgroundThe Netherlands is currently considered a low endemic country for carbapenem-resistant Enterobacterales (CRE) and carbapenemase-producing...
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A real use case of semi-supervised learning for mammogram classification in a local clinic of Costa Rica
The implementation of deep learning-based computer-aided diagnosis systems for the classification of mammogram images can help in improving the...
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High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens
BackgroundColistin (CST) is a last-line drug for multidrug-resistant Gram-negative bacterial infections. CST-heteroresistant Enterobacter cloacae ...
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Comparative Genomics of Clostridioides difficile
Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of nosocomial diarrhoea in...
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Economic Considerations in Medical Biotechnology
New products, that are often more expensive than existing treatments, are launched every year to treat various diseases. Patients, providers, and...
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Macrolide Use in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory airway disease characterized by non-reversible airflow limitation and...
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Clinical impact of endemic NDM-producing Klebsiella pneumoniae in intensive care units of the national referral hospital in Jakarta, Indonesia
ObjectiveA prospective observational study was performed to assess the epidemiology and clinical impact of carbapenem-non-susceptible Klebsiella...
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Mechanistic Understanding of Antibiotic Resistance in ESKAPE Pathogens
Antibiotic resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and...
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Antimicrobial Resistance: An Overview
Recounting the struggle against infectious diseases reconciles us with the failures. Following discovery, clinical implementation of different...
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Longitudinal genomic surveillance of carriage and transmission of Clostridioides difficile in an intensive care unit
Despite enhanced infection prevention efforts, Clostridioides difficile remains the leading cause of healthcare-associated infections in the United...
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Acinetobacter baumannii: assessing susceptibility patterns, management practices, and mortality predictors in a tertiary teaching hospital in Lebanon
BackgroundAcinetobacter baumannii is a major nosocomial pathogen capable of causing life-threatening infections. This bacterium is highly resistant...
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Nucleic Acid Amplification and Molecular Diagnostic Techniques in the Detection of ESKAPE Bacterial Pathogens
The word ESKAPE denotes a particular group of microbial species viz., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia,...