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Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay
GPCR’s receptosome operates via coordinated changes between the receptor expression, their modifications and interactions between each other....
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Dopamine Receptor Supersensitivity and Schizophrenia
Despite decades of clinical and preclinical research, the etiopathology of schizophrenia remains unknown. One of the most long-standing theories...
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On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
G protein-coupled receptors modulate the synaptic glutamate and GABA transmission of the claustrum. The work focused on the transmitter–receptor...
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Analysis and Quantification of GPCR Heteroreceptor Complexes and Their Allosteric Receptor–Receptor Interactions Using Radioligand Binding Autoradiography
G protein-coupled receptors (GPCRs) complexes and their allosteric receptor–receptor interactions represent a new fundamental principle in molecular...
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Effect of gut microbiome on serotonin metabolism: a personalized treatment approach
Several factors including diet, exercise, and medications influence the makeup of the resilient but adaptable gut microbiome. Bacteria in the gut...
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Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example
There is a large body of biochemical and biophysical experimental evidences which establishes the existence of G protein-coupled receptors (GPCRs) as...
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Pharmacology and Neurotoxicity of 5-MeO-DIPT
Psychedelics are drugs that alter consciousness and affect human psyche. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) emerged in the recreational...
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Small Interference RNA Knockdown Rats in Behavioral Functions: GALR1/GALR2 Heteroreceptor in Anxiety and Depression-Like Behavior
The gene silencing by RNA interference (RNAi) represents a new approach for inhibition of gene expression in cell culture and in vivo and it is a...
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Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease
Huntington’s (HD) and Parkinson’s diseases (PD) are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the...
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Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System
Addiction is a serious public health problem, and the current pharmacotherapy is unable to prevent drug use reinstatement. Studies have focused on...
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Physiology of Normal Sleep
Several neurotransmitter systems and circulating factors regulate rapid eye movement (REM) sleep, non-REM (NREM) sleep, and wakefulness (W). The...
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Heteroreceptor Complexes Implicated in Parkinson’s Disease
Heteromerization alters GPCR recognition, G-protein activation, receptor signaling and trafficking, thus changing receptor protomer pharmacology and...
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Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation
Vestibular compensation is a physiological response of the vestibular organs within the inner ear. This adaptation manifests during consistent...
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Salicylate Ototoxicity, Tinnitus, and Hyperacusis
Salicylate, the active ingredient in aspirin, is one of the most widely used drugs in the world. Extremely high doses of salicylate induce a...
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Dopamine Receptor Supersensitivity and Schizophrenia
Despite decades of clinical and preclinical research, the etiopathology of schizophrenia remains unknown. One of the most long-standing theories...
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The role of the brain renin-angiotensin system in Parkinson´s disease
The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues...
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Models of Diabetes in Rats: A Focus on Diabetic Neuropathy and Biomarkers
The increased prevalence of diabetic neuropathy (DN), as reported by World Health Organization, is seriously alarming. There is an unmet need to...
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Pharmacology and Neurotoxicity of 5-MeO-DIPT
Psychedelics are drugs that alter consciousness and affect human psyche. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) emerged in the recreational...
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Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia
Background/aimsThe renin-angiotensin system (RAS) is altered in Parkinson’s disease (PD), a disease due to substantia nigra neurodegeneration and...
