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RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation
BackgroundMore than 90% of the mortality of triple-negative breast cancer (TNBC) patients is attributed to cancer metastasis with organotropism. The...
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Sequential targeted exome sequencing of 1001 patients affected by unexplained limb-girdle weakness
PurposeSeveral hundred genetic muscle diseases have been described, all of which are rare. Their clinical and genetic heterogeneity means that a...
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Protein O-GlcNAcylation in cardiovascular diseases
O -GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by...
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Biosynthesis of Sialic Acid
SAs as a group of nine carbon saccharides are named nonulosonates (NulOs) or nonoses and they are mainly appeared in the animal tissues including...
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Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse models
O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial...
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Identification of differential proteomics in Epstein-Barr virus-associated gastric cancer and related functional analysis
BackgroundEpstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein...
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Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play...
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A founder mutation in the GMPPB gene [c.1000G > A (p.Asp334Asn)] causes a mild form of limb-girdle muscular dystrophy/congenital myasthenic syndrome (LGMD/CMS) in South Indian patients
Twelve patients from seven unrelated South Indian families with a limb-girdle muscular dystrophy-congenital myasthenic syndrome (LGMD/CMS) phenotype...
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Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer
Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequent oncogenic driver of solid tumors, including non-small cell lung cancer (NSCLC). The...
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Role of c-Met/HGF Axis in Altered Cancer Metabolism
c-Met (mesenchymal–epithelial transition factor) is a receptor tyrosine kinase that belongs to the Met family and is majorly expressed on the...
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Proteomic Analysis of Brain Tissue from a Chronic Model of Stress Using a Combined 2D Gel Electrophoresis and Mass Spectrometry Approach
Aging of the brain can result in excessive glucocorticoid secretion, potentially due to chronic stress and related situations. This can lead to...
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Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally with a mortality rate exceeding 95% and very limited therapeutic...
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Scalable production of tissue-like vascularized liver organoids from human PSCs
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as...
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Epithelial and stromal co-evolution and complicity in pancreatic cancer
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or fibroinflammatory response. Dominated by non-malignant cells, the...
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Congenital myasthenic syndrome in Turkey: clinical and genetic features in the long-term follow-up of patients
Congenital Myasthenic Syndromes (CMS) are rare disorders that occur as a result of defects in the structure and in the function of neuromuscular...
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Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of...
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2-Oxoglutarate-dependent dioxygenases in cancer
2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including...
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Molecular autopsy in maternal–fetal medicine
PurposeThe application of genomic sequencing to investigate unexplained death during early human development, a form of lethality likely enriched for...
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Keratinocyte-derived IL-36γ plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes
Chemical leukoderma is an acquired type of vitiligo that can be initiated by various exogenous chemicals such as hydroquinone (HQ), rhododendrol...
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