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Single-Molecule Nanomechanical Genoty** with DNA Origami-Based Shape IDs
Atomic force microscopy (AFM)-based nanomechanical imaging provides a sub-10-nm-resolution approach for imaging biomolecules under ambient...
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Detection of low-frequency mutations in clinical samples by increasing mutation abundance via the excision of wild-type sequences
The efficiency of DNA-enrichment techniques is often insufficient to detect mutations that occur at low frequencies. Here we report a DNA-excision...
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Epigenetically Modified DNA Fragments
Islet β-cell death is a hallmark of both type 1 and type 2 diabetes, resulting in decreased insulin levels. In recent years, circulating cell-free...
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DNA barcoding of black flies (Diptera: Simuliidae) in Indonesia
BackgroundDNA barcoding is a valuable taxonomic tool for rapid and accurate species identification and cryptic species discovery in black flies....
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Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores
Single-molecule quantification of the strength and sequence specificity of interactions between proteins and nucleic acids would facilitate the...
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Protein Coating of DNA Origami
DNA origamiDNAorigamis has emerged as a common technique to create custom two- (2D) and three-dimensional (3D) structures at the nanoscale. These DNA...
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GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
BackgroundDNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of cancer...
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HPV18 L1 and long control region sequences variation and E6/E7 differential expression in nasopharyngeal and cervical cancers: a comparative study
BackgroundThe role of high-risk human papillomaviruses (hr-HPVs) in cervical cancer (CC) pathogenesis has long been established. Knowledge about the...
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Regulation potential of transcribed simple repeated sequences in develo** neurons
Simple repeated sequences (SRSs), defined as tandem iterations of microsatellite- to satellite-sized DNA units, occupy a substantial part of the...
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Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C
IntroductionHIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir...
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Genetic variation of the freshwater snail Indoplanorbis exustus (Gastropoda: Planorbidae) in Thailand, inferred from 18S and 28S rDNA sequences
Indoplanorbis exustus , a freshwater pulmonate snail, is widely distributed in tropical and subtropical zones and plays a significant role as an...
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Analysis of Regulatory DNA Sequences by Dual-Luciferase Reporter Assays in Ewing Sarcoma
Reporter gene assays allow for examining the influence of regulatory DNA sequences on the transcription of target genes. In Ewing sarcoma, the study...
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Reduced representative methylome profiling of cell-free DNA for breast cancer detection
BackgroundWhole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced representative methylome...
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DNA and Its Significance in Forensic Science
The technique of DNA fingerprinting is considered as one of the enthralling innovations of the scientific era. The massive potential of the technique...
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Reconfigurable Two-Dimensional DNA Molecular Arrays
In biology, molecular cascade signaling is an essential tool to mediate various pathways and downstream behaviors. Mimicking these molecular cascades...
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DNA Condensation Processes Mediated by Metal-Based Drug Entities and Morphological Studies
The term ‘condensation’ is used to depict aggregates of a finite size with orderly morphology that are provoked by chemical agents, multivalent...
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Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma
Due to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a...
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Analysis of the Genomic Sequences and Metabolites of Bacillus velezensis YA215
Discovering more novel antimicrobial compounds has become a keen research problem. In this study, YA215 genome was sequenced by the Illumina...
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Aptamers as Functional Modules for DNA Nanostructures
Watson-Crick base-pairing of DNA allows the nanoscale fabrication of biocompatible synthetic nanostructures for diagnostic and therapeutic biomedical...
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DNA Origami: Recent Progress and Applications
This chapter explores the basic concept of DNA origami and its various types. By showing the progress made in structural DNA nanotechnology during...