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The Role of Tau Proteoforms in Health and Disease
Tau is a microtubule-associated binding protein in the nervous system that is known for its role in stabilizing microtubules throughout the nerve...
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Differential vulnerability of the dentate gyrus to tauopathies in dementias
The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia...
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Frontotemporal Lobar Degeneration TDP-43-Immunoreactive Pathological Subtypes: Clinical and Mechanistic Significance
Frontotemporal lobar degeneration with TPD-43-immunoreactive pathology (FTLD-TDP) is subclassified based on the type and cortical laminar...
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Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a...
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Tau Pathology in Neurodegenerative Diseases
Aggregation and cellular accumulation of tau protein is a defining feature of tauopathies, a class of histopathologically and clinically...
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CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers with utility for...
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Clinical and Biochemical Heterogeneity of Parkinson’s Disease
Objectives. To study the relationship between measures of oxidative stress and clinical changes in patients with neurodegenerative parkinsonism and...
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Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors
Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson’s disease and include bradykinesia, rigidity, and...
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Seed amplification and RT-QuIC assays to investigate protein seed structures and strains
The accumulation of misfolded proteins as amyloid fibrils in the brain is characteristic of most neurodegenerative disorders. These misfolded...
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The Cognitive Profile of Atypical Parkinsonism: A Meta-Analysis
Atypical Parkinsonism (AP) syndromes are characterized by a wide spectrum of non-motor symptoms including prominent attentional and executive...
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New Approaches to the Treatment of Frontotemporal Dementia
Frontotemporal dementia (FTD) comprises a diverse group of clinical neurodegenerative syndromes characterized by progressive changes in behavior,...
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Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
BackgroundPrevious studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies...
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Rhombomere 10 r10
Ascending cranially in the brainstem, this chapter deals with some more precerebellar nuclei—projecting to the cerebellum—like the lateral reticular...
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Seeding Activity of Skin Misfolded Proteins as a Biomarker in Prion and Prion-Like Diseases
Prion disease (PrD) and other prion-like diseases, including but not limited to Alzheimer’s disease (AD) and Parkinson’s disease (PD), are...
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The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
Neurodegenerative diseases encompass a heterogeneous group of conditions characterised by the progressive degeneration of the structure and function...
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The Spectrum of Tau Pathology in Human Prion Disease
Intracellular deposition of hyperphosphorylated tau characterizes tauopathies: there is a spectrum from neuron-predominant through mixed neuronal and...
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Ballooned neurons in semi-recent severe traumatic brain injury
Traumatic brain injury (TBI) is now recognized as an insult triggering a dynamic process of degeneration and regeneration potentially evolving for...
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Nigral glucose metabolism as a diagnostic marker of neurodegenerative parkinsonian syndromes
Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are characterized by nigrostriatal degeneration. We...
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Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson’s disease
BackgroundThere is a need for biomarkers to support an accurate diagnosis of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) has been a...
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An Understanding of Different Mechanisms Leading to Neurodegenerative Diseases
The prevalence of neurodegenerative disorders is rapidly increasing causing high morbidity and cognitive deterioration in the elder population....