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Role of Pharmacogenomics in Tumor and Therapeutic Outcomes
Pharmacogenomics can be understood as the tailored treatment approach based on individual genomic structure. The treatment is where drug responses...
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PI3K Isoforms in CD8+ T Cell Development and Function
CD8+ T cells are an essential part of the immune system and play a vital role in defending against tumors and infections. The...
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Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer
BackgroundThe current precision medicine relies on biomarkers, which are mainly obtained through next-generation sequencing (NGS). However, this...
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Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway
Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the...
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Role of Pharmacogenomics in Tumor and Therapeutic Outcomes
Pharmacogenomics can be understood as the tailored treatment approach based on individual genomic structure. The treatment is where drug responses...
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PI3K inhibitors are finally coming of age
Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation has spurred extensive efforts to develop therapeutic PI3K inhibitors....
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Drug resistance in ovarian cancer: from mechanism to clinical trial
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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A bibliometric analysis of the application of the PI3K-AKT-mTOR signaling pathway in cancer
PI3K-AKT-mTOR plays as important role in the growth, metabolism, proliferation, and migration of cancer cells, and in apoptosis, autophagy,...
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Therapeutic challenges in peripheral T-cell lymphoma
Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological malignancies. Compared to our knowledge of B-cell tumors, our...
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Determining drug dose in the era of targeted therapies: playing it (un)safe?
Targeted therapies against phosphatidylinositol 3-kinase (PI3K), Bruton’s tyrosine kinase (BTK), and B-cell lymphoma-2 (BCL-2) are approved for...
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Extranodal lymphoma: pathogenesis, diagnosis and treatment
Approximately 30% of lymphomas occur outside the lymph nodes, spleen, or bone marrow, and the incidence of extranodal lymphoma has been rising in the...
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PAK and PI3K pathway activation confers resistance to KRASG12C inhibitor sotorasib
BackgroundKRAS is a frequently mutated oncogene in human cancer. Clinical studies on the covalent inhibitors of the KRAS G12C mutant have reported...
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Exploring the DNA damage response pathway for synthetic lethality
Synthetic lethality (SL) describes a situation in which the occurrence of one genetic event maintains cell viability, whereas the co-occurrence of...
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Targeting DNA damage repair pathways in pancreas cancer
Pancreas ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the USA. While other cancers with historically poor prognoses...
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New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions
Advanced and recurrent gynecological cancers lack effective treatment and have poor prognosis. Besides, there is urgent need for conservative...
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Gedatolisib shows superior potency and efficacy versus single-node PI3K/AKT/mTOR inhibitors in breast cancer models
The PI3K, AKT, and mTOR (PAM) pathway is frequently dysregulated in breast cancer (BC) to accommodate high catabolic and anabolic activities driving...
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop
The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification is one of the earliest radiological indicators of knee...
