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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in...
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Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
BackgroundLuteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of...
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Clinical data mining: challenges, opportunities, and recommendations for translational applications
Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world...
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Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model
Ritlecitinib, an orally available Janus kinase 3 and tyrosine kinase inhibitor being developed for the treatment of alopecia areata (AA), is highly...
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A feasibility study for in vivo treatment verification of IMRT using Monte Carlo dose calculation and deep learning-based modelling of EPID detector response
BackgroundThis paper describes the development of a predicted electronic portal imaging device (EPID) transmission image (TI) using Monte Carlo (MC)...
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Role of Artificial Intelligence in Clinical and Hospital Pharmacy
Artificial intelligence (AI) has emerged as an influential force in various industries, with potentially revolutionary implications for healthcare....
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Good Clinical Practice in Clinical Trials, Substantial Evidence of Efficacy, and Interpretation of the Evidence
Sponsors seeking marketing authorization for a drug in the United States of America are required to demonstrate substantial evidence of effectiveness...
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Mechanism of Sophorae Flavescentis Radix against ovarian cancer via new pharmacology, molecular docking, and experimental verification
The study aims to elucidate the pharmacological mechanisms of Sophorae Flavescentis Radix (SFR, Kushen) against ovarian cancer (OV) by employing an...
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Clinical significance of TROAP in endometrial cancer and the antiproliferative and proapoptotic effects of TROAP knockdown in endometrial cancer cells: integrated utilization of bioinformatic analysis and in vitro test verification
Trophinin-associated protein (TROAP), a cytoplasmic protein essential for spindle assembly and centrosome integrity during mitosis, has been reported...
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Identification and verification of a BMPs-related gene signature for osteosarcoma prognosis prediction
BackgroundThis study aimed to get a deeper insight into new osteosarcoma (OS) signature based on bone morphogenetic proteins (BMPs)-related genes and...
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A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification
BackgroundChronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma (HCC). However, the mechanism of hepatitis...
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Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification
The study aimed to utilize network pharmacology combined with cell experiments to research the mechanism of action of Saikosaponin-d in the treatment...
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Network pharmacology and experimental verification study on the mechanism of Hedyotis diffusa Willd in treating colorectal cancer
This study aimed to evaluate the pharmacological mechanism of Hedyotis diffusa Willd against CRC (colorectal cancer) using network pharmacological...
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Establishment and verification of prognostic model and ceRNA network analysis for colorectal cancer liver metastasis
ObjectsColorectal cancer (CRC) is one of the most common cancers in the world. Approximately two-thirds of patients with CRC will develop colorectal...
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Verification of nucleotide sequence reagent identities in original publications in high impact factor cancer research journals
Human gene research studies that describe wrongly identified nucleotide sequence reagents have been mostly identified in journals of low to moderate...
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Identification of a basement membrane-related genes signature with immune correlation in bladder urothelial carcinoma and verification in vitro
BackgroundBladder urothelial carcinoma (BLCA) is the most common genitourinary cancer and the prognosis of patients is often poor. However, studies...
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Clinical implementation of HyperArc
The aim of this study was to present our experience on clinical implementation of HyperArc including dosimetric comparison between VMAT and HyperArc...
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A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management
BackgroundHigh-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond...
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Curvature correction factors for the independent verification of monitor units of electron treatment plans calculated in Eclipse
Electron beam dosimetry is sensitive to the surface contour of the patient. Over 10% difference between Treatment Planning System (TPS) and...
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Decentralisation in Clinical Trials and Patient Centricity: Benefits and Challenges
Decentralised clinical trials (DCTs) encompass various terms such as virtual, home-based, remote and siteless trials. The objectives of DCTs are to...
