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Epigenetics of Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with non-suppurative destruction of the intrahepatic bile ducts. The...
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Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome
Overlap syndromes (OSs) between primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) represent rare forms of PBC and AIH. The diagnosis...
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Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis
Susceptibility to primary biliary cholangitis (PBC) is in part genetically determined. In our previous PBC genome-wide association study (GWAS) in...
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Regional heritability map** identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population
While the advent of GWAS more than a decade ago has ushered in remarkable advances in our understanding of complex traits, the limitations of...
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Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders
BackgroundChronic liver diseases constitute a major global public health burden, posing a substantial threat to patients’ daily lives and even...
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The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia
Unlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets...
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Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study
BackgroundEpidemiological studies have indicated a potential link between the gut microbiome and autoimmune liver disease (AILD) such as autoimmune...
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The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts
Autoimmune liver diseases are a group of immune-mediated liver diseases with three distinct entities, including autoimmune hepatitis, primary biliary...
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Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases
BackgroundChanges in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis...
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Genetic association and causal relationship between multiple modifiable risk factors and autoimmune liver disease: a two-sample mendelian randomization study
BackgroundThe intricate etiology of autoimmune liver disease (AILD) involves genetic, environmental, and other factors that yet to be completely...
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Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target
The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA),...
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Clinical and Immunological Features, Genetic Variants, and Outcomes of Patients with CD40 Deficiency
PurposeInherited deficiencies of CD40 and CD40 ligand (CD40L) reflect the crucial immunological functions of CD40–CD40L interaction/signaling....
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Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022
BackgroundEdwardsiella tarda is a member of Enterobacteriaceae isolated from freshwater and sea. E. tarda infection in humans commonly causes...
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Proteomics in Primary Biliary Cholangitis
Primary biliary cholangitis is a chronic cholestatic liver disease characterized by the presence of serum antimitochondrial antibodies and...
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Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis
Background & AimsAnti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients...
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Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease
Autoimmune liver diseases (AILD) include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC)....
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Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis
Purinergic signaling is important in the activation and differentiation of macrophages, which play divergent roles in the pathophysiology of liver...
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rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases
CD58 plays roles in cell adhesion and co-stimulation with antigen presentation from major histocompatibility complex class II on antigen-presenting...
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Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells
Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver homeostasis. How...
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Opisthorchiasis
Opisthorchiasis is a parasitic infestation of the bile duct and gall bladder of humans, commonly caused by the liver flukes Opisthorchis viverrini...