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Quantitative susceptibility map** from basal ganglia and related structures: correlation with disease severity in progressive supranuclear palsy
ObjectiveWe examined whether mean magnetic susceptibility values from deep gray matter structures in patients with progressive supranuclear palsy...
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Cortical and subcortical morphological alteration in Angelman syndrome
BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder with serious seizures. We aim to explore the brain morphometry of patients with AS...
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Decreased Local Specialization of Brain Structural Networks Associated with Cognitive Dysfuntion Revealed by Probabilistic Diffusion Tractography for Different Cerebral Small Vessel Disease Burdens
To reveal the network-level structural disruptions associated with cognitive dysfunctions in different cerebral small vessel disease (CSVD) burdens,...
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Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy
Previous studies have indicated a potential relationship between zinc and epilepsy. The aim of this study is to investigate the causal relationship...
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CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state
This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context...
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Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity
Obesity is related to overconsumption of high-calorie (HiCal) food, which is modulated by brain reward and inhibitory control circuitries. The basal...
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The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain
BackgroundThe mechanisms underlying neurodegeneration in the striatum of Huntingon’s Disease (HD) brain are currently unknown. While the striatum is...
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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder...
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Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains...
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Frontal-striatal glucose metabolism and fatigue in patients with multiple sclerosis, long COVID, and COVID-19 recovered controls
This study compared brain glucose metabolism using FDG-PET in the caudate nucleus, putamen, globus pallidus, thalamus, and dorsolateral prefrontal...
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Resting-state functional connectivity-based parcellation of the human dentate nucleus: new findings and clinical relevance
For years, the cerebellum was left out of functional magnetic resonance imaging (fMRI) studies due to technological limitations. The advent of novel...
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Simultaneous Four Supratentorial Lesions Predict Tube Dependency Due to an Impaired Anticipatory Phase of Ingestion
This study aimed to identify the neuroanatomical predictors of oropharyngeal dysphagia and tube dependency in patients with supratentorial or...
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Modeling nucleus accumbens
Nucleus accumbens is part of the neural structures required for reward based learning and cognitive processing of motivation. Understanding its...
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The relationship between dorsal stream connections to the caudate and verbal fluency in Parkinson disease
Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of...
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Dopaminergic and nitric oxide systems interact to regulate the electrical activity of neurons in the medial septal nucleus in rats
Research characterizing the neuronal substrate of anxiety has implicated different brain areas, including the medial septal nucleus (m-SEPT)....
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Dopamine D2/3 Receptor Availabilities in Striatal and Extrastriatal Regions of the Adult Human Brain: Comparison of Four Methods of Analysis
Values of binding potentials ( BP ND ) of dopamine D 2/3 receptors differ in different regions of the brain, but we do not know with certainty how much...
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[18F]-FDopa positron emission tomography imaging in corticobasal syndrome
PurposeFirst, to investigate the patterns of [ 18 F]-FDOPA positron emission tomography imaging in corticobasal syndrome using visual and...
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Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline
BackgroundSubjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The...
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Prenatal Amphetamine-Induced Dopaminergic Alteration in a Gender- and Estrogen-Dependent Manner
Prenatal exposure to amphetamine induces changes in dopamine receptors in mesolimbic areas and alters locomotor response to amphetamine during...
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Disrupted topological organization of functional brain networks in traumatic axonal injury
Traumatic axonal injury (TAI) may result in the disruption of brain functional networks and is strongly associated with cognitive impairment....