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Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures
The presence of tertiary lymphoid structures (TLS) is correlated with prolonged patient survival in a variety of solid cancers, including melanoma....
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Tertiary lymphoid structures in cancer – considerations for patient prognosis
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional...
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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular ‘immunity hubs’...
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Tissue-specific features of innate lymphoid cells in antiviral defense
Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s,...
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Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer
BackgroundWe previously proposed an immune cell score (tumour node metastasis (TNM)-Immune cell score) classifier as an add-on to the existing TNM...
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Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME)....
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Regulation of Cancer Development and Evolution by Innate Lymphoid Cells
Immune surveillance mechanisms are essential for the identification and elimination of altered cells that, left unchecked, may give rise to cancer....
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Lymphatic vessels in the age of cancer immunotherapy
Lymphatic transport maintains homeostatic health and is necessary for immune surveillance, and yet lymphatic growth is often associated with solid...
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The chromatin-associated RNAs in gene regulation and cancer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into proteins or execute gene regulatory functions. Many RNAs...
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The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
Cancer is a complex disease, and despite incredible progress over the last decade, it remains the leading cause of death worldwide. Liver cancers,...
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Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses
Tumors poorly infiltrated by T cells are more resistant to immunogenic chemotherapies and checkpoint inhibition than highly infiltrated tumors. Using...
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Breast tumor microenvironment structures are associated with genomic features and clinical outcome
The functions of the tumor microenvironment (TME) are orchestrated by precise spatial organization of specialized cells, yet little is known about...
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B cells in head and neck squamous cell carcinoma: current opinion and novel therapy
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which...
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Tertiary lymphoid structures in the era of cancer immunotherapy
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including...
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Basics of Inducible Lymphoid Organs
Tertiary lymphoid organs (TLOs), also known as inducible lymphoid organs, tertiary lymphoid structures, tertiary lymphoid tissues, or ectopic...
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Tumor Immune Microenvironment of Soft Tissue Sarcoma
Soft tissue sarcoma (STS) is a group of cancers transformed from mesenchymal cells. The treatment outcome of immunotherapy has not been as successful...
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Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation
Aging has multifaceted effects on the immune system, but how aging affects tissue-specific immunity is not well-defined. Bladder diseases...
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Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
BackgroundThe TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include...
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Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
PurposeMelanoma is widely utilized as a prominent model for the development of immunotherapy, thought an inadequate immune response can occur....
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Sex differences in the aging murine urinary bladder and influence on the tumor immune microenvironment of a carcinogen-induced model of bladder cancer
Sex and age associated differences in the tumor immune microenvironment of non-muscle invasive bladder (NMIBC) cancer and associated clinical...
