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Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants
BackgroundPolymorphisms in the interleukin-10 ( IL10 ) gene have been linked to the severity of the patients infected with the viral infections. This...
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Osteogenic Commitment of MSC Is Enhanced after Interaction with Umbilical Cord Blood Mononuclear Cells In Vitro
The effectiveness of stroma-dependent expansion of hematopoietic cells ex vivo may depend on the level of commitment of multipotent mesenchymal...
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Performance of the National Institute of Infectious Diseases disability scale in HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling disease. However, there is a lack of an adequate and...
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Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis
BackgroundPsoriasis (Ps) is a chronic dermatosis characterized by erythematous-squamous plaques derived from an inflammatory response. The effect of...
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Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case–control study
BackgroundSingle-nucleotide polymorphisms (SNPs) and DNA methylation are crucial regulators of essential hypertension (EH). Amyloid precursor protein...
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Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis
Tick-borne encephalitis (TBE) is a neuroviral disease that ranges in severity from a mild febrile illness to a severe and life-threatening...
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Fluid biomarkers for amyotrophic lateral sclerosis: a review
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. Presently, three...
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Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
BackgroundAlzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits...
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Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Based on emerging evidence on the role for specific single-nucleotide variants (SNVs) in EIF2AK3 encoding the integrated stress response kinase PERK,...
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Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level?
The multidrug resistance (MDR) phenotype characterizes patients with refractory epilepsy (RE). Seizures are not controlled despite receiving various...
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Serotype distribution of Streptococcus pneumoniae among healthy carriers and clinical patients: a systematic review from Iran
Streptococcus pneumoniae is associated with high morbidity and mortality in the world. Commercially licensed and available pneumococcal conjugate...
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Pharmacogenetics of ATP binding cassette transporter MDR1(1236C>T) gene polymorphism with glioma patients receiving Temozolomide-based chemoradiation therapy in Indian population
Temozolomide (TMZ), an alkylating agent with a broad-spectrum antitumor activity, ability to cross blood–brain barrier (BBB), shown to be effective...
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Donor CSF3R with the rs3917980A/G or G/G genotype is correlated with better leukemia-free survival after allogenic hematopoietic stem cell transplantation
Polymorphisms in the granulocyte colony-stimulating factor receptor gene (GCSFR, CSF3R) have been reported to be associated with peripheral blood...
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Extranodal lymphoma: pathogenesis, diagnosis and treatment
Approximately 30% of lymphomas occur outside the lymph nodes, spleen, or bone marrow, and the incidence of extranodal lymphoma has been rising in the...
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Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
BackgroundIdiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition...
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Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation
ObjectiveOngoing neuroaxonal damage is a major contributor to disease progression and long-term disability in multiple sclerosis. However,...
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Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies
Esophageal cancer remains one of the most challenging cancers to treat, with a poor prognosis due to factors such as late detection, high mortality...