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Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) was the third most common cause of cancer death. But it has only limited therapeutic options, aggressive nature, and...
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Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor
Intracranial mesenchymal tumor (IMT), FET::CREB fusion-positive is a provisional tumor type in the 2021 WHO classification of central nervous system...
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Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
Glutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem...
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Long non-coding RNAs HERH-1 and HERH-4 facilitate cyclin A2 expression and accelerate cell cycle progression in advanced hepatocellular carcinoma
BackgroundThe advanced hepatocellular carcinoma (HCC), such as the recurrent tumor after liver transplantation (LT), is an obstacle of HCC treatment....
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Increased β-adrenergic stimulation augments vascular smooth muscle cell calcification via PKA/CREB signalling
In chronic kidney disease (CKD), hyperphosphatemia promotes medial vascular calcification, a process augmented by osteogenic transdifferentiation of...
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MACE-Seq-based coding RNA and TrueQuant-based small RNA profile in breast cancer: tumor-suppressive miRNA-1275 identified as a novel marker
IntroductionDisruption of cellular processes in the breast by abnormally expressed miRNA is characterized to develop cancer. We aimed to identify the...
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Riluzole Attenuates L-DOPA-Induced Abnormal Involuntary Movements Through Decreasing CREB1 Activity: Insights from a Rat Model
Chronic administration of L-DOPA, the first-line treatment of dystonic symptoms in childhood or in Parkinson’s disease, often leads to the...
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Genetic and clinical determinants of mizoribine pharmacokinetics in renal transplant recipients
AimMizoribine (MZR) is an immunosuppressant for the prevention of allograft rejection in Asian countries, but the great variability in...
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Machine learning and bioinformatics analysis revealed classification and potential treatment strategy in stage 3–4 NSCLC patients
BackgroundPrecision medicine has increased the accuracy of cancer diagnosis and treatment, especially in the era of cancer immunotherapy. Despite...
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Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approach
BackgroundRett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the methyl-CpG-binding protein 2 gene ( MECP2 ). MeCP2 is...
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HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) versus adult T-cell leukemia/lymphoma (ATLL)
ObjectivesHuman T cell leukemia virus-1 (HTLV-1) infection may lead to one or both diseases including HTLV-1-associated myelopathy/tropical spastic...
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MicroRNAs as Potential Biomarkers in Huntington’s Disease
MicroRNAs (miRNAs) play an essential role in many physiological processes of our body. Dysregulation of miRNAs is involved in the pathology of...
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BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription
BackgroundBoth multiple myeloma (MM) and systemic lupus erythematosus (SLE) are associated with abnormal production of plasma cells, although their...
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Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics...
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Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice
BackgroundHeart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by...
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Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders
BackgroundExposure to traffic-related air pollution (TRAP) during development and/or in adulthood has been associated in many human studies with both...
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Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in adult acute myeloid leukemia
BackgroundTSC22D domain family genes, including TSC22D1-4, play a principal role in cancer progression. However, their expression profiles and...
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Crimean-Congo Haemorrhagic Fever Virus: A Complete Overview
The Crimean-Congo haemorrhagic fever virus (CCHFV) is an arbovirus that is spread by ticks. Transmission with this virus has been documented in the...
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The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different...
