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Optogenetic Modulation of the Visceromotor Response to Reveal Visceral Pain Mechanisms
Visceral pain is a debilitating condition that is common yet lacks effective treatments. In the case of gastrointestinal disorders (e.g.,...
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Olov Oscarsson (1931–1996) of Lund University, a Pioneer in Cerebellar Neurobiology
The present Cerebellar Classic highlights the experimental work of the Swedish neurophysiologist Olov Oscarsson (1931–1996) on the afferent...
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Prior perineural or neonatal treatment with capsaicin does not alter the development of spinal microgliosis induced by peripheral nerve injury
Peripheral nerve injury is associated with spinal microgliosis which plays a pivotal role in the development of neuropathic pain behavior. Several...
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Central and peripheral contributions of T-type calcium channels in pain
Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among...
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Ex Vivo Skin-Teased Fiber Recordings from Tibial Nerve
Ex vivo skin-nerve recordings are an electrophysiological technique used to characterize and measure primary sensory afferent activity. In this...
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Effects of exercise induced muscle damage on cardiovascular responses to isometric muscle contractions and post-exercise circulatory occlusion
PurposeThe aim of the present study was to investigate whether exercise-induced muscle damage (EIMD) influences cardiovascular responses to isometric...
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Diabetes mellitus and hearing loss
Diabetes mellitus (DM) is a major disease threatening human health and its incidence is increasing year on year. As a chronic complication of DM,...
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Single-Unit Electrophysiological Recordings of Primary Muscle Sensory Neurons Using a Novel Ex Vivo Preparation
For decades, multiple electrophysiological techniques have been used to characterize the responses of primary afferents to a variety of stimuli under...
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Of Mice and Men and Plethysmography Systems: Does LKB1 Determine the Set Point of Carotid Body Chemosensitivity and the Hypoxic Ventilatory Response?
Our recent studies suggest that the level of liver kinase B1 (LKB1) expression in some way determines carotid body afferent discharge during hypoxia...
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Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
BackgroundInflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β)...
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Rebound Depolarizations
The deep cerebellar nuclei (DCN) are critical in defining the output of the cerebellum. The DCN are positioned at the base of cerebellum where they...
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The Teleost Fish
In vertebrates, the basic structure of the central nervous system, including the cerebellum, is conserved from mammals to teleosts. The cerebellum of...
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A Novel Paired Somatosensory-Cerebellar Stimulation Induces Plasticity on Cerebellar-Brain Connectivity
The cerebellum receives and integrates a large amount of sensory information that is important for motor coordination and learning. The aim of the...
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Fastigial Nucleus Input/Output Related to Motor Control
The cerebellar cortex is morphologically homogenous but can be separated into compartments based on distinct input/output patterns. Therefore, the...
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Map** Synaptic Inputs to Oligodendroglial Cells Using In Vivo Monosynaptic Viral Tracing
Oligodendroglial precursor cells (OPCs) are a non-neuronal cell type in the brain that receives synaptic inputs. Electrophysiological and...
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Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
Mechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical allodynia in somatic chronic pain conditions....
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Rhombomere 6 r6
In this chapter, an important sensory system is described: the auditory system, with the cochlear part of CNVIII, including and anticipating the...
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Affective Touch: Psychophysics, Physiology and Vicarious Touch Perception
It is hypothesized that the affective quality of touch is conveyed through the stimulation of a group of unmyelinated low threshold mechanoreceptors...
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Use of Optogenetics for the Study of Skin–Nerve Communication
This chapter describes the use of light-activated opsin proteins for study of keratinocyte and immune cell communication with sensory neurons that...
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Fiber Anatomy of the Brainstem and Implications for Surgery of Brainstem Tumors
The anatomical design of the brainstem is one of the most fascinating and intriguing components of the human brain. The brainstem is composed of both...