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Effects of Ran-GTP/importin β inhibition on the meiotic division of porcine oocytes
The Ran-GTP/importin β pathway has been implicated in a diverse array of mitotic functions in somatic mitosis; however, the possible meiotic roles of...
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Autophagy in Stem Cell Maintenance and Differentiation
AutophagyAutophagy is one of the intracellular machinery for maintaining organelle as well as physiological homeostasis in cells by clearance of...
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Neural Stem Cells and Brain Tumour Models in Drosophila
During development organs and tissues grow in size. This growth can be achieved either by increasing the size of individual cells or by increasing...
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Stem Cell Culture and Its Applications
Cells are the structural and functional unit of life. The dynamics of life encompass the continuous interaction of the cells with the environment and...
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Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease
The small intestine is among the fastest self-renewing tissues in adult mammals. This rapid turnover is fueled by the intestinal stem cells residing...
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Nonmammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery
This chapter provides an overview of hair cell regeneration in nonmammalian vertebrates. First, we review the early foundational research on hair...
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Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
BackgroundSorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in...
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How mechanisms of stem cell polarity shape the human cerebral cortex
Apical–basal progenitor cell polarity establishes key features of the radial and laminar architecture of the develo** human cortex. The unique...
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PAR-4 in the Regulation of Stem Cell Death and Embryo Development
Prostate apoptosis response-4 (PAR-4) is widely known to induce apoptosis in cancer cells, suggesting that it may also regulate cell death in other...
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Biophysical and Biochemical Mechanisms Underlying Collective Cell Migration in Cancer Metastasis
Multicellular collective migration is an ubiquitous strategy of cells to translocate spatially in diverse tissue environments to accomplish a wide...
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Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration
Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a...
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Par-4 in Cell Cycle Regulation
Cell cycle must be carefully controlled to ensure genetic materials are replicated once and only once per cycle and equal sister chromatid...
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High-throughput spatiotemporal monitoring of single-cell secretions via plasmonic microwell arrays
Methods for the analysis of cell secretions at the single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell...
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Inner Ear Cells from Stem Cells: A Path Towards Inner Ear Cell Regeneration
Investigating the mammalian inner ear’s sensory epithelia has been limited by the lack of accessibility, being embedded in dense bone, and further...
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Quantification of Muscle Satellite Stem Cell Divisions by High-Content Analysis
High-content screeningScreening is commonly performed on 2D cultured cells, which is high throughputHigh throughput but has low biological relevance....
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Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinoma
BackgroundNuclear receptor subfamily 1 group H member 4 (NR1H4) have been reported in various cancer types, however, little is known about the...
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The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Resistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially...
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Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer
BackgroundDishevelled paralogs (DVL1, 2, 3) are key mediators of Wnt pathway playing a role in constitutive oncogenic signaling influencing the tumor...
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MEF2C regulates NK cell effector functions through control of lipid metabolism
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset of transcription factors can...
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Early Neurogenesis and Gliogenesis in Drosophila
In Drosophila, neurons and glial cells derive from neural precursor cells called neuroblasts glioblasts or neuroglioblasts. These neural precursor...