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Traditional Chinese Medicines for Malaria Therapy
Malaria, one of the “big three” killer diseases, is a major public health problem as well as a major cause of mortality and morbidity worldwide. The...
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Drug Discovery from Natural Sources
Purpose of ReviewA discussion of the role of natural products as drugs and/or following partial or complete chemical synthesis, have been approved...
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A review on reported phytochemicals as druggable leads with antimalarial potential
The science and practice of drug discovery and development is primarily benefitted from the natural sources. The chemistry of natural products has...
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Artemisin and human endometrial-derived stem cells improve cognitive function and synaptic plasticity in a rat model of Alzheimer disease and diabetes
Alzheimer disease (AD) is a common form of dementia associated with loss of memory and disruption of synaptic plasticity. There is a strong...
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Role of Plant Secondary Metabolites as Anticancer and Chemopreventive Agents
Cancer is a life-threatening disease, and its treatment is a challenge for medical science since its inception. This disease is characterized by...
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Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies
Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer...
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Terpenoids as Chemopreventive Agents and Their Interpretation in Animal Models and Human Clinical Trials
Cancer chemoprevention is described as the utilization of substances of natural or synthetic origin to interfere in the discrete early stages of...
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A Comparison Study of Medicinal Plants Used Against SARS-CoV-2 and Those Recommended Against Malaria in Africa
Coronavirus disease 2019 (COVID-19) and malaria are two different diseases but both lead to serious crisis in public health in Africa. These two...
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Anti-malarial drug use, appropriateness and associated factors among children under-five with febrile illnesses presenting to a tertiary health facility: a cross sectional study
BackgroundMalaria is endemic in 95% of Uganda and constitutes the country’s most significant public health problem—being the leading cause of...
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Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents
A series of novel chalcone derivatives were synthesized and investigated against the chloroquine-sensitive P. falciparum 3D7 ( Pf 3D7) strain and...
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Healthcare professionals’ perspective can guide post-marketing surveillance of artemisinin-based combination therapy in Uganda
BackgroundEfficient testing to identify poor quality artemisinin-based combination therapy (ACT) is important to optimize efforts to control and...
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The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers
BackgroundThe emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds,...
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Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action
BackgroundMalaria remains one of the most virulent and deadliest parasitic disease in the world, particularly in Africa and Southeast Asia....
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Natural Drugs Through Plant Cell Suspension Culture
Throughout ancient history, plants have been harnessed for their phytochemical components, particularly the secondary metabolites. These compounds,...
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A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score
BackgroundMalaria, a treatable disease mainly caused by Plasmodium falciparum has remained a health challenge in Africa, a continent that accounted...
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Antimicrobial Resistance: A Crisis in the Making
Antimicrobial resistance (AMR) is considered the silent pandemic that threatens the global public health systems and one of the biggest threats to...
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Curcumin potentiates the anti-inflammatory effects of Tehranolide by modulating the STAT3/NF-κB signaling pathway in breast and ovarian cancer cell lines
BackgroundStudies have demonstrated that natural products, such as curcumin and artemisinin, possess anti-inflammatory effects, which can be...
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Collection and Cryopreservation of Plasmodium falciparum Clinical Isolates in the Field
P. falciparum causes the most severe form of malaria in younger children and pregnant women. In vitro culture systems allow researchers to understand...
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Nanotechnology in the Formulation and Delivery of Natural Products for Cancer
Cancer represents one of the most known life-threatening health disorders, which has inflicted a heavy burden on individual lives owing to high...
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Polymeric Micelles in the Delivery of Therapeutic Phytoconstituents
Since ancient times, medicinal plants and their phytochemical constituents have been utilized to cure a number of diseases. Currently, various herbal...