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Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies
Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. Quercetin and its derivatives like...
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Pharmacoresistance in Epilepsy
Although more than 30 anti-seizure medications are available on the market, epilepsy remains pharmaco-resistant in 30% of patients with focal...
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GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments....
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Noninvasive Brain Stimulation as a Potential Therapeutic Procedure in Drug-Resistant Epilepsy
About only 5% of all patients with drug-resistant epilepsy can be considered candidates for surgery. Consequently, there is an enhancing interest in...
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Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medications. It is of utmost...
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Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuating spontaneous recurrent...
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Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats
It is still an urgent need to find alternative and effective therapies to combat epileptic seizures. Tacrolimus as a potent immunosuppressant and...
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Sleep and Epilepsy
In people with epilepsy, sleep may be disrupted by nocturnal epileptic activity as well as by the use of antiseizure medications (ASM). Conversely...
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Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level?
The multidrug resistance (MDR) phenotype characterizes patients with refractory epilepsy (RE). Seizures are not controlled despite receiving various...
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Experimental Models for the Study of Drug-Resistant Epilepsy
Drug-resistant epilepsy is a major health problem that has not diminished despite the existence of new antiepileptic drugs. The use of appropriate...
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Ketogenic Diet and Drug-Resistant Epilepsy
The ketogenic diet is a high-fat, low-carbohydrate, and restricted protein diet that is used in children with drug-resistant epilepsy. Over the past...
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Drug-Resistant Epilepsy and the Influence of Age, Gender, and Comorbid Disorders
In the study of drug-resistant epilepsy (DRE), certain important characteristics remain poorly understood such as the age and gender of patients and...
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Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy
Experimental data suggest a role of blood–brain barrier P-glycoproteinP-glycoprotein (P-gp) overexpression as a factor contributing to drug-resistant...
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Screening Platforms for Genetic Epilepsies—Zebrafish, iPSC-Derived Neurons, and Organoids
Recent advances in molecular and cellular engineering, such as human cell reprogramming, genome editing, and patient-specific organoids, have...
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Physical Exercise as a Strategy to Reduce Seizure Susceptibility
Neuroprotective and antiepileptogenic therapies have been extensively used for prevention and treatment of epilepsy. This chapter focuses on the...
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Impact of REM Sleep on Sleep Disorders: Current Perspectives
Sleep is a complex process characterized by different stages, including rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. Throughout...
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Effects of Transcranial Focal Electrical Stimulation Via Concentric Ring Electrodes on Seizure Activity
Epilepsy affects approximately one percent of the planet’s population. There does not appear to be any single therapy that works for all types of...
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Vagus Nerve Stimulation for Intractable Seizures
Vagus nerve stimulation (VNS) is the most widely used non-pharmacological treatment for drug-resistant epilepsy (DRE) since its approval by the FDA...
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Iron and Epilepsy
Epilepsy is a disorder defined by repeated, recurrent, and temporary impairment of the brain (CNS) caused by an abnormally rhythmic discharge of...
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Effect of a Ketogenic Diet on Oxidative Posttranslational Protein Modifications and Brain Homogenate Denaturation in the Kindling Model of Epilepsy in Mice
This study focused on the ketogenic diet (KD) effects on oxidative posttranslational protein modification (PPM) as presumptive factors implicated in...
