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Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling. We investigated whether...
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Molecular probes for the human adenosine receptors
Adenosine receptors, G protein–coupled receptors (GPCRs) that are activated by the endogenous ligand adenosine, have been considered potential...
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Adenosine receptor signalling in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better...
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Adenosine as a Key Mediator of Neuronal Survival in Cerebral Ischemic Injury
Several experimental studies have linked adenosine’s neuroprotective role in cerebral ischemia. During ischemia, adenosine is formed due to...
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The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior
The role of peripheral adenosine receptors in pain is a controversial issue and seems to be quite different from the roles of spinal and central...
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On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity
ObjectiveTo ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of...
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Purinergic P2 Receptors in Epilepsy
Despite continuous advances in the understanding of the underlying pathogenesis of hyperexcitable networks and lowered seizure threshold, treatment...
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Aberrant adenosine signaling in patients with focal cortical dysplasia
Focal cortical dysplasia (FCD), a common malformation of cortical development, is frequently associated with pharmacoresistant epilepsy in both...
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Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes
Anxiety involves abnormal glucocorticoid signalling and altered glia-neuron communication in brain regions processing emotional responses. Adenosine A
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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. In this context, purinergic...
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A1 Adenosine Receptor Activation Inhibits P2X3 Receptor–Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons
Purinergic signaling is involved in multiple pain processes. P2X3 receptor is a key target in pain therapeutics, while A1 adenosine receptor...
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The role of adenosine A1 receptor on immune cells
BackgroundAdenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A 1 , A 2 A, A 2 B, and A 3 ),...
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Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors
Ischemia is characterized by a transient, insufficient, or permanent interruption of blood flow to a tissue, which leads to an inadequate glucose and...
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Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A1 receptors for the potential treatment of epilepsy
Due to the implication of adenosine in seizure suppression, adenosine-based therapies such as adenosine receptor (AR) agonists have been...
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Adenosine Pathway in Genitourinary Malignancies: A Promising Immunotherapeutic Target
Pathways involved in adenosine metabolism have emerged as an exciting drug target in different types of cancers. Mechanistically it is proposed that...
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Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling
Accumulating evidence suggest that ghrelin plays a role as an antiseptic peptide. The present study aimed to clarify whether the brain may be...
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Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK+ATP-Channels in Rat Brain When Exposed to Intermittent Hypoxia
AbstractThe mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and its combination with hypoxia are not studied...
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The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish
Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures. The high prevalence of comorbidities associated with epilepsy,...
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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
BackgroundStreptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust...
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Cross Talk on P2X4 Purinergic Receptors and Neuropathic Pain
Purpose of ReviewConsiderable interest has been paid to purinergic receptors, a group of cell surface receptors that react to extracellular purines...
