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Stimulators of immunogenic cell death for cancer therapy: focusing on natural compounds
A growing body of evidence indicates that the anticancer effect of the immune system can be activated by the immunogenic modulation of dying cancer...
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Hypoxic 3D Tumor Model for Evaluating of CAR-T Cell Therapy In Vitro
Solid tumors contain abnormal physical and biochemical barriers that hinder chimeric antigen receptor (CAR) T cell therapies. However, there is a...
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CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy
Today, cancer treatment is one of the fundamental problems facing clinicians and researchers worldwide. Efforts to find an excellent way to treat...
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CAR-T cell combination therapy: the next revolution in cancer treatment
In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer...
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The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
The adaptive immune system and associated inflammation are vital in surveillance and host protection against internal and external threats, but can...
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CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
CAR T cell-based therapies have revolutionized the treatment of hematological malignancies such as leukemia and lymphoma within the last years. In...
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Relapse after CAR-T cell therapy in B-cell malignancies: challenges and future approaches
Chimeric antigen receptor-T (CAR-T) cell therapy, as a novel cellular immunotherapy, has dramatically reshaped the landscape of cancer treatment,...
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Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived mesenchymal stromal cells (MSCs) have been most frequently...
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Biological causes of immunogenic cancer cell death (ICD) and anti-tumor therapy; Combination of Oncolytic virus-based immunotherapy and CAR T-cell therapy for ICD induction
Chimeric antigen receptor (CAR) T-cell therapy is a promising and rapidly expanding therapeutic option for a wide range of human malignancies....
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Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy,...
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The safety and efficacy of volumetric modulated Arc therapy combined with computer tomography-guided adaptive brachytherapy for locally advanced cervical cancer: a single institution experience
BackgroundVolumetric modulated arc therapy (VMAT) is a novel form of IMRT, which can deliver more accurate dose distribution and shorten treatment...
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Adipokines at the crossroads of obesity and mesenchymal stem cell therapy
Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract metabolic syndromes, including obesity and its comorbid...
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Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner
BackgroundEnhancing the response rate of immunotherapy will aid in the success of cancer treatment. Here, we aimed to explore the combined effect of...
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Cell-derived biomimetic nanoparticles for the targeted therapy of ALI/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical critical diseases with high morbidity and mortality....
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FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of...
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Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results
The T cell receptor fusion construct (TRuC) gavocabtagene autoleucel (gavo-cel) consists of single-domain anti-mesothelin antibody that integrates...
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Expansion and Retroviral Transduction of Primary Murine T Cells for CAR T-Cell Therapy
The development of chimeric antigen receptor (CAR) T cells has been a revolutionary technology for the treatment of relapsed and refractory leukemias...
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Nanomedicine in Immune System Therapy
With the advent of nanotechnology, the prospects for using engineered nanomaterials (NMs) with diameters of <100 nm in industrial applications,...
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Cancer Therapy
Current cancer therapy is based on surgery, radiotherapy, chemotherapy, and immunotherapy, often administered in combination. Cytotoxic chemotherapy...
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Immunological barriers to haematopoietic stem cell gene therapy
Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the transformative potential of regenerative medicine. Recent clinical...
