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Immune disguise: the mechanisms of Neu5Gc inducing autoimmune and transplant rejection
Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc (N-hydroxyacetylneuraminic acid) is a pathogenic...
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Comprehensive characterization of immunogenic cell death in acute myeloid leukemia revealing the association with prognosis and tumor immune microenvironment
BackgroundThis study aimed to explore the clinical significance of immunogenic cell death (ICD) in acute myeloid leukemia (AML) and its relationship...
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Analysis of Chemokine-to-GAG Interactions in Model of Donor Renal Allograft Transplant
Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine...
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Multi-omics network characterization reveals novel microRNA biomarkers and mechanisms for diagnosis and subty** of kidney transplant rejection
BackgroundKidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is...
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Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury
ObjectivesPrimary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of...
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The effect of acute exercise on attentional control and theta power in young adults
Exercise has a profound impact on one’s health, and it is becoming increasingly accepted that exercise also benefits cognitive functioning. Yet, the...
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Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Despite the use of various therapies such as hematopoietic stem cell transplantation and chimeric antigen receptor T cell therapy (CAR-T), the...
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The Biology and Molecular Basis of Organ Transplant Rejection
Allograft rejection is defined as tissue injury in a transplanted allogeneic organ produced by the effector mechanisms of the adaptive alloimmune...
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The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development
BackgroundThe interplay between Toxoplasma gondii infection and tumor development is intriguing and not yet fully understood. Some studies showed...
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Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
BackgroundPatients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose...
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Quercetin attenuates Pseudomonas aeruginosa-induced acute lung inflammation by inhibiting PI3K/AKT/NF-κB signaling pathway
Pseudomonas aeruginosa is an opportunistic pathogen that commonly causes infections in immunocompromised individuals with significant morbidity and...
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Acute ethanol disrupts conditioned inhibition in the male rat
RationaleAlcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also be induced using...
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Exosomes from dendritic cells with Mettl3 gene knockdown prevent immune rejection in a mouse cardiac allograft model
We have previously demonstrated that Mettl3-silencing dendritic cells (DCs) exhibited immature properties and prolonged allograft survival in a...
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Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients
IntroductionA new type of immune cell transplantation called allogeneic NK cell infusion is proposed as a potential universal off-the-shelf cell...
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A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection
In organ transplantation, infection and rejection are major causes of graft loss. They are linked by the net state of immunosuppression. To diagnose...
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Identification of TACSTD2 as novel therapeutic targets for cisplatin-induced acute kidney injury by multi-omics data integration
Cisplatin-induced acute kidney injury (CP-AKI) is a common complication in cancer patients. Although ferroptosis is believed to contribute to the...
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An automated histological classification system for precision diagnostics of kidney allografts
For three decades, the international Banff classification has been the gold standard for kidney allograft rejection diagnosis, but this system has...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Targeting Acute Inflammation
Understanding the immune response in the central nervous system (CNS) is essential for the development of new therapeutic concepts in multiple...
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Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
The pathogenesis of allograft (dys)function has been increasingly studied using ‘omics’-based technologies, but the focus on individual organs has...
