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Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
The intracellular protozoan Eimeria tenella is responsible for avian coccidiosis which is characterized by host intestinal damage. During...
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Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
ObjectiveTo analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated...
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Let it glow: genetically encoded fluorescent reporters in Plasmodium
The use of fluorescent proteins (FPs) in Plasmodium parasites has been key to understand the biology of this obligate intracellular protozoon. FPs...
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Toxoplasma gondii: Asexual Cycle in the Intermediate Host
Toxoplasma gondii is a parasite of major medical and veterinary importance with a high incidence in humans. This coccidian parasite has a complex...
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Structural patterns of selection and diversity for Plasmodium vivax antigens DBP and AMA1
BackgroundPlasmodium vivax is a significant contributor to the global malaria burden, and a vaccine targeting vivax malaria is urgently needed. An...
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Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL
BackgroundThe ability to report vaccine-induced IgG responses in terms of µg/mL, as opposed arbitrary units (AU), enables a more informed...
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HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya
BackgroundHIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell...
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Measuring antibody avidity to Plasmodium falciparum merozoite antigens using a multiplex immunoassay approach
BackgroundAntibodies (Ab) play a significant role in immunity to Plasmodium falciparum malaria. Usually, following repeated exposure to pathogens,...
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Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses
Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s...
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Eimeria proteins: order amidst disorder
Apicomplexans are important pathogens that cause severe infections in humans and animals. The biology and pathogeneses of these parasites have shown...
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Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia
BackgroundPlasmodium falciparum parasite populations in Ethiopia have been experiencing local selective pressures from drugs and immunity, leading...
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Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children
BackgroundThe FcγRs genotypes have been reported to play a key role in the defence against malaria parasites through both cellular and humoral...
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Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort
BackgroundSubstantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from...
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Assessment of Plasmodium falciparum Antigen-Specific B Cells
This protocol describes methods that exploit the specificity of binding between the B cell receptor and cognate antigen to detect and characterize...
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A human antibody epitope map of the malaria vaccine antigen Pfs25
Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly...
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Malaria attributable fractions with changing transmission intensity: Bayesian latent class vs logistic models
BackgroundAsymptomatic carriage of malaria parasites is common in high transmission intensity areas and confounds clinical case definitions for...
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Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A
BackgroundA malaria vaccine based on Plasmodium falciparum apical membrane antigen 1 (AMA1) elicited strain specific efficacy in Malian children...
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Characterization of PSOP26 as an ookinete surface antigen with improved transmission-blocking activity when fused with PSOP25
BackgroundThe Plasmodium zygote-to-ookinete developmental transition is an essential step for establishing an infection in the mosquito vector, and...
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Immunodiagonsis of Malaria
Malaria remains one of the world’s most important public health threats, and prompt, precise diagnosis is still an essential component of malaria...
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Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study
BackgroundIn non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety...
