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Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their in vitro cyclooxygenase, 5-lipoxygenase, and tumour...
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Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2
The monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacologically for anti-inflammatory...
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Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis
Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in...
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Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis
Fungal keratitis (FK) is a vision-threatening infection. We aimed to explore the antifungal and anti-inflammatory effects of pseudolaric acid B (PAB)...
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Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning
Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident...
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Animal Models for Small Cell Lung Cancer Research: Current Status and Future Perspectives
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor characterized by enhanced proliferation rate and rapid early metastasis with low...
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Interplay between androgen and CXCR4 chemokine signaling in myelin repair
In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling...
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Correlation between LOX-1 and CX3CR1 and Vascular Endothelial Function, Fibrinolytic Activity, and Recurrence after Thrombolysis in Patients with Cerebral Infarction
AbstractThis study analyzed the relationship between LOX-1 and CX3CR1 and vascular endothelial function, fibrinolytic activity, and recurrence rate...
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Novel antiarthritic mechanisms of Azelaic acid against CFA-induced arthritis in rats by modulating pro- and anti-inflammatory cytokines network
An immunologic system attacking the body’s own tissues is a hallmark of autoimmune disorders, which encompass a wide range of unique conditions....
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Future Perspectives of Oxytosis/Ferroptosis Research in Neurodegeneration Diseases
The current report briefly summarizes the existing hypotheses and relevant evidence of oxytosis/ferroptosis-mediated cell death and outlines future...
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Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
BackgroundPICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed...
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Inflammation Resolution Mediators: Future Prospects
Inflammation resolution is a complex system that involves a variety of lipid mediators, proteins, hormones, and gaseous mediators that act in a...
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Renin–Angiotensin–Aldosterone System and LOX-1 Interaction in Hypertension with a Focus on Modulation of the Immune System
The renin–angiotensin–aldosterone systemRenin-angiotensin-aldosterone system (RAAS) plays a key role in the pathological process of many...
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S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma
BackgroundExcess body weight has been found to associate with an increased risk of lymphomas and some metabolic pathways are currently recognized in...
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Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
Tumors are highly complex and heterogenous ecosystems where malignant cells interact with healthy cells and the surrounding extracellular matrix...
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Causal roles and clinical utility of cardiovascular proteins in colorectal cancer risk: a multi-modal study integrating mendelian randomization, expression profiling, and survival analysis
PurposeThis comprehensive investigation delved into the intricate causal interplay existing between cardiovascular-related plasma proteins and the...
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Limitation and Termination of the Immune Response: Influences of Food Components on the Downregulation and Termination of the Immunological Defense Response
Immune reactions must occur in a spatially and temporally limited manner within the framework of physiological homeostasis. Specific functional food...
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Immunotherapy for Pancreatic Cancer
Pancreatic cancer is currently the fourth leading cause of cancer-related deaths with a high fatality rate, and is predicted to become the second...
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Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
Thiazolidinediones are useful antidiabetic medications. However, their use is associated with adverse side effects like edema, heart failure and bone...
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Evaluation of anti-inflammatory effects of polyherbal decoction, balaguluchyadi kashayam
Inflammation is a natural defense mechanism of the body, however, persistent inflammatory responses lead to a variety of chronic inflammatory...
