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Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy
Treatment of glioblastoma multiforme (GBM) remains challenging. Unraveling the orchestration of glutamine metabolism may provide a novel viewpoint on...
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A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism
BackgroundMTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism....
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Micropeptides: origins, identification, and potential role in metabolism-related diseases
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode...
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Acetyl-CoA metabolism in cancer
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during...
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a...
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Bcl-3 regulates T cell function through energy metabolism
BackgroundBcl-3 is a member of the IκB protein family and an essential modulator of NF-κB activity. It is well established that Bcl-3 is critical for...
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Prognosis prediction based on methionine metabolism genes signature in gliomas
BackgroundGlioma cells have increased intake and metabolism of methionine, which can be monitored with 11 C-L-methionine. However, a short half-life...
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Group-specific cellular metabolism in Medulloblastoma
BackgroundCancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research...
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STAT proteins in cancer: orchestration of metabolism
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of cancer, from tumour initiation through disease progression and...
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Advance in Multi-omics Research Strategies on Cholesterol Metabolism in Psoriasis
The skin is a complex and dynamic organ where homeostasis is maintained through the intricate interplay between the immune system and metabolism,...
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The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis
In the development of Alzheimer’s disease (AD), cell death is common. Novel cell death form—ferroptosis is discovered in recent years. Ferroptosis is...
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Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise
Alzheimer’s disease (AD) is a major subtype of neurodegenerative dementia caused by long-term interactions and accumulation of multiple adverse...
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LncRNA RPARP-AS1 promotes the progression of osteosarcoma cells through regulating lipid metabolism
Osteosarcoma (OS) is a highly malignant tumor, and its dysregulated lipid metabolism is associated with tumorigenesis and unfavorable prognosis....
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Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications
Autism spectrum disorder (ASD) is a mosaic of neurodevelopmental conditions composed of early-onset social interaction and communication deficits,...
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Targeting glutamine metabolism as a therapeutic strategy for cancer
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids...
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Iron metabolism: backfire of cancer cell stemness and therapeutic modalities
Cancer stem cells (CSCs), with their ability of self-renewal, unlimited proliferation, and multi-directional differentiation, contribute to...
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The role of AMPK in macrophage metabolism, function and polarisation
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays a key role in regulating...
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Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Abstract —Coordinated regulation of energy conversion processes in the brain maintains its highly productive work and efficient mental activity....
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Iron Metabolism and Ferroptosis in Early Brain Injury after Subarachnoid Haemorrhage
At present, it appears that the prognosis for subarachnoid haemorrhage (SAH), which has a high death and disability rate, cannot be greatly improved...
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Thymidine nucleotide metabolism controls human telomere length
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely...
