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The Epidermal Growth Factor Family
During the purification of nerve growth factor from mouse submaxillary glands by carboxymethyl cellulose chromatography, distinct biological...
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Complex chromosome rearrangements: Report of three patients
Three unrelated patients are described, each with a complex, de novo chromosome rearrangement involving four or more break points. One of the patients...
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Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children
The expression of common fragile sites at 69 bands was evaluated in 20 normal children and in 15 children with newly diagnosed acute leukemia using...
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Rapid RFLP screening procedure identifies new polymorphisms at albumin and alcohol dehydrogenase loci
A rapid screening procedure for restriction fragment length polymorphisms (RFLPs) is reported. DNA from ten individuals is pooled and compared to DNA...
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Variation in the expression of aphidicolin-induced fragile sites in human lymphocyte cultures
A correlation between specific fragile sites and cancer breakpoints has been suggested raising the question of fragile site expression as a...
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Genetics of Human Alcohol and Aldehyde Dehydrogenases
During the past 5 years considerable progress has been made in the elucidation of the biochemical genetics of human alcohol dehydrogenases (ADH) and...
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Cell Hybridization and the 24 Human Gene Maps
The transfer of genes is an ancient phenomenon in the biology and evolution of organisms, as is evidenced by a variety of microorganisms. In bacteria...
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Persistence and Expression of the Epstein-Barr Virus Genome in Latent Infection and Growth Transformation of Lymphocytes
Epstein-Barr Virus (EBV) is believed to be an important etiologic agent of nasopharyngeal cancers (NPC) especially of the anaplastic type since (i)...
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The critical monosomic segment involved in 4p- syndrome: A high-resolution banding study on five inherited cases
In an attempt to determine the critical monosomic segment involved in 4p- syndrome, we studied the precise breakpoints of five inherited cases with...
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DNA replication and inactivation patterns in structural abnormality of sex chromosomes
High resolution chromosome analysis and bromodeoxyuridine (BrdUrd) incorporation have been applied to study patterns of chromosomal replication...
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Assigning the polymorphic human insulin gene to the short arm of chromosome 11 by chromosome sorting
We have determined the subchromosomal location of the human insulin gene by analyzing DNA isolated from sorted human metaphase chromosomes. Metaphase...
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Partial trisomies 9 and 4 resulting from maternal translocation t(4; 9) (q25?; q13)
A female infant of partial trisomies 9 and 4 resulting from a maternal balanced translocation was described. The karyotype was designated as...
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Partial trisomy 4q in two unrelated cases
Two unrelated cases of 4q trisomy are described with trisomic segment 4q25→4qter. The most conspicuous symptoms are psychomotor retardation,...
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Partial trisomy 4q: Two cases with a familial translocation t(4;18)(q27;q23)
Clinical and cytogenetic data of two related patients, both trisomic for the segment 4q27→qter, are reported. Familial studies determined that the...
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A case of distal 4q trisomy due to familial (4;5)(q31;p15) translocation
A boy with multiple anomalies including atresia of the esophagus, ventricular septal defect, horseshoe kidney and some minor anomalies is described....
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Partial trisomy 4q due to familial 2/4 translocation
The case of a 5-year-old boy with partial trisomy for the long arm of chromosome No. 4 is described. The pattern of abnormal development in this and...