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Testing Efficacy of Natural Anxiolytic Compounds
Anxiety disorders are a group of mental disorders that range in their severity from occasional, brief episodes of relatively benign... -
Neurotrophic factors as novel therapeutics for neuropathic pain
Neuropathic pain is a chronic condition that is caused by injury to the nervous system. Unlike acute pain, which is protective, neuropathic pain...
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Phenylalanine kinetics are associated with tardive dyskinesia in men but not in women
Rationale : An association between tardive dyskinesia (TD) and severely impaired metabolism of the large neutral amino acid (LNAA), phenylalanine...
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Marihuana: Effects on Neuronal Excitability and Seizure Threshold
In the late 19th century, British neurologists found that cannabis had a limited role in epilepsy therapy. Cannabinoid receptors are found in the... -
Phenytoin and Congeners
The synthesis of 5,5-diphenylhydantoin was reported by Biltz in 1908. In 1937 Putnam and Merrutt reported that it elevated the threshold to... -
Pharmacological effects and mechanisms of action
Valproate (valproic acid; usually used as its sodium salt), also referred to as di-n-propylacetic acid, is a simple eight-carbon branched-chain fatty... -
Anticoagulants
Anticoagulants have been used clinically for over half a century and are critical for the adequate treatment of a variety of health- and... -
Self-reported use of antidepressants or benzodiazepine tranquilizers and risk of epithelial ovarian cancer: evidence from two combined case-control studies (Massachusetts, United States)
Data from two population-based case-control studies in the greater metropolitan Boston, MA (USA) were used to assess the association of self-reported...
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Pharmacotherapy and Pathophysiology of Alcohol Withdrawal
The alcohol withdrawal syndrome has received increased attention over the past 40 years and it is now well established that the abrupt reduction, or... -
A glycinergic intervention potentiates the antiseizure efficacies of MK-801, flurazepam, and carbamazepine
Twenty four hours after mice were forced to swim for up to 10 minutes in cold water, there was a reduction in the ability of MK-801 to antagonize the...
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Biomechanical approach to quantifying anticipatory postural adjustments in the elderly
The paper outlines a biomechanical approach to quantifying anticipatory postural adjustments in the elderly. The measurement problems that occur in...
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Spinal cord seizures: a possible cause of isolated myoclonic activity in traumatic spinal cord injury
Spinal cord seizures are infrequently reported. They have been associated with intravenous dye placement, transverse myelitis and multiple sclerosis,...
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Diagnosis and Treatment of Drug Overdose
Interest in drug overdosage has changed in recent years, because of the extension of drug abuse to all segments of society, the advent of new drugs... -
Effects of phenobarbital, clonazepam, valproic acid, ethosuximide, and phenytoin on the delayed matching-to-sample performance of pigeons
The effects of phenobarbital, clonazepam, valproic acid, ethosuximide, and phenytoin were examined in pigeons performing under a delayed...
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