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Optical Sensor for the Determination of Glucose Based on KIO4 Chemiluminescence Detection
A method to determine glucose using an optical sensor prepared by entrap** glucose oxidase into silica sol-gel column has been developed. The...
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Time-Resolved Fluorescent Imaging of Glucose
A method for the fluorescent imaging of glucose is described that is based on the detection of enzymatically produced hydrogen peroxide, using the...
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Synthesis, Characterization, and Luminescence Spectroscopic Accessibility Studies of tris(2,2′-Bipyridine)Ruthenium(II)-Labeled Inorganic-Organic Hybrid Polymers
The modified tris (2,2′-bipyridine)ruthenium(II) complex 2 was anchored via a sol-gel process to different polysiloxane matrices to give a series of...
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Antiviral Drug Target Discovery with DNA Microarrays
Global expression analysis with DNA microarrays is exquisitely suited to monitor changes in mRNA levels arising from disturbances of the cellular... -
Acute Intermittent Porphyria: Expression of Mutant and Wild-Type Porphobilinogen Deaminase in COS-1 Cells
BackgroundAcute intermittent porphyria (AIP) is an autosomal dominant disorder that results from the partial deficiency of porphobilinogen deaminase...
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The Pathology of Cerebral Malaria
Blockage of cerebral microvessels by Plasmodium falciparum-infected erythrocytes appears to be the principal cause of the pathology of cerebral... -
Sequence-Selective Groove Binders
A large number of agents are known to bind to DNA, interfering with multiple DNA functions in living cells. Their ability to interact with DNA is... -
Detection of a high mutation frequency in exon 12 of the porphobilinogen deaminase gene in patients with acute intermittent porphyria
Direct cDNA sequencing was performed on asymmetrically amplified transcripts from the porphobilinogen deaminase (PBG-D) gene of thirteen unrelated...
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Electrometric immunoassay
The diagnostics markets accounted for sales of US $8500 million worldwide in 1989 (1). Within these markets, immunodiagnostics accounted for $3000... -
Modified electrode surface in amperometric biosensors
The electron transfer reactions of biological molecules are frequently very slow at ordinary electrodes. To overcome this problem, and thus to...
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The Design of an Artificial Olfactory System
The aim of our research is to design an instrument which will mimic the human sense of smell. This ambition distinguishes our approach from that used... -
Uroporphyrinogen III cosynthetase activity in fibroblasts from patients with congenital erythropoietic porphyria
The activity of uroporphyrinogen III cosynthetase is lower in extracts of fibroblasts from patients with congenital erythropoietic porphyria than in...
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Uroporphyrinogen III cosynthetase in asymptomatic carriers of congenital erythropoietic porphyria
Mean activity of the enzyme uroporphyrinogen III cosynthetase in hemolysates from five asymptomatic carriers of bovine erythropoietic porphyria was...