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Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor...
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Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
Status epilepticus (SE) in humans is characterized by prolonged convulsive seizures that are generalized and often difficult to control. The current...
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Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats
It has been shown that prostaglandin (PG) E 2 synthesized in the lateral parabrachial nucleus (LPBN) is involved in lipopolysaccharide-induced fever....
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The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine
The intestinal epithelium is covered by mucus that protects the tissue from the luminal content. Studies have shown that anion secretion via the...
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Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke
As the inducible terminal enzyme for prostaglandin E2 (PGE 2 ) synthesis, microsomal PGE synthase-1 (mPGES-1) contributes to neuroinflammation and...
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Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
BackgroundTo examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 ( mPGES-1) inhibitor, in...
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NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling
Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. Here, we identify a...
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Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin E2 synthases in physiology and host–parasite interactions
BackgroundThe salmon louse ( Lepeophtheirus salmonis ) is a parasite of salmonid fish. Atlantic salmon ( Salmo salar ) exhibit only a limited and...
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Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1
BackgroundMicrosomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in...
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E-cigarette effects on vascular function in animals and humans
Smoking tobacco cigarettes is a significant (cardiovascular) health risk factor. Although the number of tobacco cigarette users declined over the...
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Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155
Abstract BackgroundProstaglandin is one of the key metabolites for inflammation-related carcinogenesis. Despite the microRNA-155 is implicated in...
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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2
Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we...
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Inhibition of COX-2 signaling favors E. coli during urinary tract infection
BackgroundTo avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhibition, have been...
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A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice
BackgroundONO-1301 is a novel long-lasting prostaglandin (PG) I 2 mimetic with inhibitory activity on thromboxane (TX) A 2 synthase. This drug can...
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C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation
C-C motif chemokine ligand 2 (CCL2) has been reported to be expressed in the bovine endometrium during pregnancy. However, the details of its...
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Ablation of Siglec-E augments brain inflammation and ischemic injury
Sialic acid immunoglobulin-like lectin E (Siglec-E) is a subtype of pattern recognition receptors found on the surface of myeloid cells and functions...
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Prostaglandin A2 Interacts with Nurr1 and Ameliorates Behavioral Deficits in Parkinson’s Disease Fly Model
The orphan nuclear receptor Nurr1 is critical for the development, maintenance, and protection of midbrain dopaminergic neurons. Recently, we...
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Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene
BackgroundGlioblastoma (GBM) is the most common primary malignant brain tumor in adults exhibiting infiltration into surrounding tissues, recurrence,...
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Regulation of liver regeneration by prostaglandin E2 and thromboxane A2 following partial hepatectomy in rats
The implication of prostaglandin E 2 (PGE 2 ) and thromboxane A 2 (TXA 2 ) in the striking process of liver regeneration has been previously reported....
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Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue
The endocannabinoid system and prostaglandins are important modulators in the genitourinary system. This study aimed to investigate the possible...
