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Regionalization of the Early Nervous System
In this chapter, we focus on observations that were made in the field of comparative nervous system development by studies carried out in Drosophila...
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Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps
Surgery is unanimously regarded as the primary strategy to cure solid tumors in the early stages but is not always used in advanced cases. However,...
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The Regionalization of Medical Management: The Practice and Exploration of Established Fudan-Minhang Medical Alliance
The Fudan-Minhang medical alliance focuses on develo** a healthcare system that considers the medical, educational, and research aspects of...
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Gastrointestinal epithelial innate immunity—regionalization and organoids as new model
The human gastrointestinal tract is in constant contact with microbial stimuli. Its barriers have to ensure co-existence with the commensal bacteria,...
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From cognitive maps to spatial schemas
A schema refers to a structured body of prior knowledge that captures common patterns across related experiences. Schemas have been studied...
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Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2
Specification of the progenitors’ regional identity is a pivotal step during development of the cerebral cortex and basal ganglia. The molecular...
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Genetic characterization of Toxoplasma gondii from human and chicken isolates from Argentina
This study aimed to determine the nPCR-RFLP genotypes of newly obtained T. gondii isolates from human congenital toxoplasmosis cases in Argentina and...
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Methylation analysis by targeted bisulfite sequencing in large for gestational age (LGA) newborns: the LARGAN cohort
BackgroundIn 1990, David Barker proposed that prenatal nutrition is directly linked to adult cardiovascular disease. Since then, the relationship...
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Unfolding the ventral nerve center of chaetognaths
BackgroundChaetognaths are a clade of marine worm-like invertebrates with a heavily debated phylogenetic position. Their nervous system superficially...
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Development and Developmental Disorders of the Cerebral Cortex
The cerebral cortex can be divided into a large isocortex, a much smaller allocortex (the hippocampal formation and the olfactory cortex), and a...
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Associated factors of prosthetic rehabilitation in specialized dental care in Brazil: a cross-sectional study
ObjectiveThis study aimed to analyze the individual and contextual factors associated with prosthetic rehabilitation in Dental Specialty Centers...
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From structural modalities in perinatal medicine to the frequency of preterm birth
Preterm birth is a global health problem that affects 11% of all live births: it remains a significant cause of death and an important cause of...
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Elevated expression of LPCAT1 predicts a poor prognosis and is correlated with the tumour microenvironment in endometrial cancer
BackgroundEndometrial cancer (EC) is one of the three malignant reproductive tumours that threaten women’s lives and health. Glycerophospholipids...
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Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis
The primate hippocampus includes the dentate gyrus, cornu ammonis (CA), and subiculum. CA is subdivided into four fields (CA1-CA3, plus CA3h/hilus of...
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Spatial Organization of Gene Expression in Systems of Cellular Differentiation and Autoimmune Diseases
The importance of the spatial distribution of genes and gene regulation areas in an organism’s genome has seen an increased interest in studies in...
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Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also...
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Identification of unique DNA methylation sites in Kabuki syndrome using whole genome bisulfite sequencing and targeted hybridization capture followed by enzymatic methylation sequencing
BackgroundKabuki syndrome (KS) is a congenital malformation syndrome caused by mutations in the KMT2D and KDM6A genes that encode histone...
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Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study
Most neurodegenerative disorders, including the two most common, Alzheimer’s disease (AD) and Parkinson’s disease (AD), course with activation of...
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Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to...
