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Pathological regression of primary tumour and metastatic lymph nodes following chemotherapy in resectable OG cancer: pooled analysis of two trials
BackgroundNo definitive largescale data exist evaluating the role of pathologically defined regression changes within the primary tumour and lymph...
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Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer
BackgroundPatients with triple-negative breast cancer (TNBC) develop early recurrence. While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2...
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The Cancer Stem Cell and Tumour Progression
Tumour stem cells result from genetic or chromosomal changes in normal tissue stem cells, i.e. cells with self-renewal capability. Subsequent tumour...
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Incidental finding of leukaemia in circulating tumour DNA— the importance of a molecular tumour board
As the use of liquid biopsies are increasing across multiple indications in cancer medicine, the detection of incidental findings on circulating...
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines
The clinical prospects of cancer nanomedicines depend on effective patient stratification. Here we report the identification of predictive biomarkers...
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Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager
The broader clinical use of bispecific T cell engagers for inducing anti-tumour toxicity is hindered by their on-target off-tumour toxicity and the...
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A timeline of tumour-associated macrophage biology
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the...
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Primary tumour immune response and lymph node yields in colon cancer
BackgroundThe mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to...
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Tumour-derived small extracellular vesicles contribute to the tumour progression through resha** the systemic immune macroenvironment
BackgroundTumour-derived small extracellular vesicles (sEVs) play a crucial role in cancer immunomodulation. In addition to tumour immune...
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Tumour-on-a-Chip: Perfusion Systems to Model the Extracellular Breast Tumour Microenvironment—From Tumour Progression to Metastasis Formation
The integration of three-dimensional (3D) tumour models in perfusion systems has provided new tools to study cancer and metastasis. Such systems are...
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Severely polarized extracellular acidity around tumour cells
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer...
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Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention
Comprehensive tumour characterisation is indispensable for patients to receive targeted therapy. The use of liquid biopsy, particularly circulating...
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How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from...
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Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers
Liver cancer is one of the most prevalent cancers, and the third most common cause of cancer-related mortality worldwide. The therapeutic options for...
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Resha** the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers, especially those...
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The tumour microenvironment, treatment resistance and recurrence in glioblastoma
The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an...
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME)....
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification
N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the most common epigenetic modification in mammalian mRNA. M6A modifications...
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Multiplex protein imaging in tumour biology
Tissue imaging has become much more colourful in the past decade. Advances in both experimental and analytical methods now make it possible to image...
