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Dantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in rats
RationaleHyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme...
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Hyperthermia inhibits cellular function and induces immunogenic cell death in renal cell carcinoma
BackgroundIn recent years, hyperthermia has been widely applied as a novel strategy for cancer treatment due to its multiple antitumour effects. In...
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Sequence variants in malignant hyperthermia genes in Iceland: classification and actionable findings in a population database
Malignant hyperthermia (MH) susceptibility is a rare life-threatening disorder that occurs upon exposure to a triggering agent. MH is commonly due to...
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ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
BackgroundIn recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However,...
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Synergistic effects of thermosensitive liposomal doxorubicin, mild hyperthermia, and radiotherapy in breast cancer management: an orthotopic mouse model study
Liposome formulations of the cancer drug doxorubicin have been developed to address the severe side effects that result from administration of this...
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Triple modal treatment comprising with proton beam radiation, hyperthermia, and gemcitabine/nab-paclitaxel for locally advanced pancreatic cancer: a phase I/II study protocol (TT-LAP trial)
BackgroundLocally advanced pancreatic ductal adenocarcinoma (PDAC), accounting for about 30% of PDAC patients, is difficult to cure by radical...
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Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility
PurposeAs a ClinGen Expert Panel (EP) we set out to adapt the American College of Medical Genetics and Genomics (ACMG)/Association for Molecular...
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Modeling of interstitial microwave hyperthermia for hepatic tumors using floating sleeve antenna
Microwave hyperthermia is a treatment modality that uses microwaves to destroy cancer cells by increasing their temperature to 41–45 °C. This study...
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Self-regulating novel iron oxide nanoparticle-based magnetic hyperthermia in swine: biocompatibility, biodistribution, and safety assessments
Studies demonstrating the successful and safe application of magnetic hyperthermia in large animals are scarce. A therapeutic approach for advanced...
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Modeling of Thermal Processes in Prostate Tumors
Heat exchange processes in prostate glands containing malignant tumors were modeled mathematically by numerical solution of the heat and mass...
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Organoids derived from patients provide a new opportunity for research and individualized treatment of malignant peritoneal mesothelioma
BackgroundMalignant peritoneal mesothelioma (MPM) is an extremely rare and highly invasive tumor. Due to the lack of accurate models that reflect the...
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Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes
BackgroundUterine serous cancer (USC) is the most common non-endometrioid subtype of uterine cancer, and is also the most aggressive. Most patients...
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STAC3 disorder: a common cause of congenital hypotonia in Southern African patients
STAC3 disorder, or Native American myopathy, is characterised by congenital myopathy, hypotonia, musculoskeletal and palatal anomalies, and...
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Temperature Dependence of Thermal Properties of Ex Vivo Porcine Heart and Lung in Hyperthermia and Ablative Temperature Ranges
This work proposes the characterization of the temperature dependence of the thermal properties of heart and lung tissues from room temperature up...
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Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1
AbstractPazopanib—a multitargeted tyrosine kinase inhibitor with prominent antiangiogenic effects—has shown promise in the treatment of soft-tissue...
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Drug-associated non-pyrogenic hyperthermia: a narrative review
PurposeHyperthermia occurs when heat accumulation surpasses the body’s ability for heat dissipation. Many drugs may affect thermoregulation. This...
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Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
BackgroundThe dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient,...
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Electrochemotherapy of skin metastases from malignant melanoma: a PRISMA-compliant systematic review
The main treatment of MM metastases are systemic therapies, surgery, limb perfusion, and intralesional talimogene laherparepvec. Electrochemotherapy...
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Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes
Chemotherapy plays an important role in debulking tumors in advance of surgery and/or radiotherapy, tackling residual disease, and treating...
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Hyperthermic Treatment by Superparamagnetic Iron Oxide Nanoparticles for Targeted Tumor Therapy: An In-Vivo Approach Guided by Swept-Source Optical Coherence Tomography
PurposeHyperthermia, also known as overheating, is a therapeutic procedure in which tissues are heated from the normal physiological ranges....
