Search
Search Results
-
Circulating metabolome landscape in Lynch syndrome
Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting...
-
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several states across the epithelial–mesenchymal landscape, thereby...
-
The immunosuppressive landscape in tumor microenvironment
Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer...
-
HIRA vs. DAXX: the two axes sha** the histone H3.3 landscape
H3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression...
-
Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or...
-
Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds
BackgroundDomesticated pigs serve as an ideal animal model for biomedical research and also provide the majority of meat for human consumption in...
-
Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review
Stroke is an acute cerebrovascular disease resulting from either obstruction or rupture of a blood vessel in the brain. Oxidative stress (OS),...
-
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression
Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune component. Knowledge of the GBM...
-
Longitudinal multi-omics analysis uncovers the altered landscape of gut microbiota and plasma metabolome in response to high altitude
BackgroundGut microbiota is significantly influenced by altitude. However, the dynamics of gut microbiota in relation to altitude remains undisclosed.
...
-
The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications
Breast cancer is the most common malignant tumor globally as of 2020 and remains the second leading cause of cancer-related death among female...
-
GRAMM Web Server for Protein Docking
Prediction of the structure of protein complexes by docking methods is a well-established research field. The intermolecular energy landscapes in...
-
Defining the landscape of metabolic dysregulations in cancer metastasis
Metastasis is the primary cause of cancer related deaths due to the limited number of efficient druggable targets. Signatures of dysregulated cancer...
-
MMP-11 expression in early luminal breast cancer: associations with clinical, MRI, pathological characteristics, and disease-free survival
BackgroundEarly hormone-positive breast cancers typically have favorable outcomes, yet long-term surveillance is crucial due to the risk of late...
-
Exploring the landscape of symbiotic diversity and distribution in unicellular ciliated protists
BackgroundThe eukaryotic-bacterial symbiotic system plays an important role in various physiological, developmental, and evolutionary processes....
-
Optimizing exoskeleton assistance to improve walking speed and energy economy for older adults
BackgroundWalking speed and energy economy tend to decline with age. Lower-limb exoskeletons have demonstrated potential to improve either measure,...
-
Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products
The current perspective reviews the biopharmaceutical market until end of 2020 and highlights the transforming biopharmaceutical landscape during the...
-
Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection
ObjectiveWe aimed to reveal a spatial proteomic and immune signature of kidney function regions in lupus nephritis (LN).
Material and methods ...
-
Bio-inspired, task-free continual learning through activity regularization
The ability to sequentially learn multiple tasks without forgetting is a key skill of biological brains, whereas it represents a major challenge to...
-
RF energy harvesters for wireless sensors, state of the art, future prospects and challenges: a review
The power consumption of portable gadgets, implantable medical devices (IMDs) and wireless sensor nodes (WSNs) has reduced significantly with the...
-
Molecular landscape of IDH-mutant astrocytoma and oligodendroglioma grade 2 indicate tumor purity as an underlying genomic factor
BackgroundIDH-mutant astrocytoma and oligodendroglioma have an indolent natural history and are recognized as distinct entities of neoplasms. There...
