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Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor
Chalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13...
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Molecular signatures in prion disease: altered death receptor pathways in a mouse model
BackgroundPrion diseases are transmissible and fatal neurodegenerative diseases characterized by accumulation of misfolded prion protein isoform (PrP
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Role of ROS in Triggering Death Receptor-Mediated Apoptosis
Reactive oxygen species (ROS) are continuously produced and removed in live systems. In different concentrations, ROS has beneficial or harmful...
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Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death
Cardiac myocyte death is an essential initiator of the pathogenesis and progression of various etiological cardiomyopathies, including diabetic...
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Death-associated protein 3 in cell death and beyond
Death-associated protein 3 (DAP3) is a highly conserved guanosine triphosphate (GTP) binding protein. As a component of the mitochondrial ribosome...
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Regulation of tight junction proteins and cell death by peroxisome proliferator-activated receptor γ agonist in brainstem of hypertensive rats
The decrease in tight junction proteins and their adapter proteins in the hypertensive brain is remarkable. Here, we aimed to investigate tight...
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Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways
Chemotherapy causes undesirable long-term neurological sequelae, chemotherapy-induced cognitive impairment (CICI), or chemobrain in cancer survivors....
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Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death
Transient receptor potential mucolipin-1 (TRPML1) is the most abundantly and widely expressed channel protein in the TRP family. While numerous...
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Alternate Programmed Cell Death Signaling in Antiviral Host Defense
This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book...
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Alterations in Receptor Genes in Huntington’s Disease
In this chapter, we explored the alterations in receptor genes associated with Huntington’s disease (HD). The dysfunction and composition of receptor...
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Cell death by phagocytosis
Cells can die as a consequence of being phagocytosed by other cells — a form of cell death that has been called phagotrophy, cell cannibalism,...
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Cell Death and Replicative Senescence in Cancer
For continuous growth, cancer cells must overcome barriers posed by terminal differentiation, replicative senescence, and cell death by apoptosis....
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The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis
Death receptors are transmembrane proteins that can induce the activation of caspase-8 upon ligand binding, initiating apoptosis. Recent work has...
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Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
BackgroundT cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid...
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Cell death in the lateral geniculate nucleus, and its possible relationship with nicotinic receptors and sudden infant death syndrome (SIDS)
The role of the lateral geniculate nucleus (LGN) in vision has been extensively studied, yet its extraretinal capacities are still being...
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Disulfidptosis: A new type of cell death
Disulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis,...
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Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells
The hypothalamic–pituitary–adrenal (HPA) system plays an important role in stress response. Chronic stress is thought to induce neuronal damage and...
