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Biomarkers in Renal Cell Carcinoma
Renal cell carcinoma (RCC) constitutes 90% of all kidney tumours. It also accounts for higher mortality rates of up to 30–40% as compared to prostate...
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The Role of Immunotherapy in Renal Cell Carcinoma
Immunotherapy has long played an integral role in the treatment of advanced renal cell carcinoma, beginning with interleukin-2 and interferon-α and...
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Renal Cell Carcinomas
This chapter highlights the molecular mechanisms in some of the many different tumor types that originate in the adult kidney. Renal cell carcinomas...
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Evolution of cell therapy for renal cell carcinoma
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with...
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Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
BackgroundClear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to...
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Characterization of renal artery variation in patients with clear cell renal cell carcinoma and the predictive value of accessory renal artery in pathological grading of renal cell carcinoma: a retrospective and observational study
ObjectiveTo explore the characteristics of renal artery variation in patients with renal cell carcinoma and to evaluate the predicting value of...
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CCDC25 suppresses clear cell renal cell carcinoma progression by LATS1/YAP-mediated regulation of the hippo pathway
BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most prevalent renal cancers, and the molecular mechanisms underlying its progression...
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Hyperthermia inhibits cellular function and induces immunogenic cell death in renal cell carcinoma
BackgroundIn recent years, hyperthermia has been widely applied as a novel strategy for cancer treatment due to its multiple antitumour effects. In...
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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic,...
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The mitochondrial fusion-associated protein MFN2 can be used as a novel prognostic molecule for clear cell renal cell carcinoma
BackgroundMitofusin 2 (MFN2) plays an important role in many tumors, but how its role in renal clear cell carcinoma needs further research.
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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
BackgroundDespite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of...
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Prognostic Significance of Tumor-Associated Inflammation in Renal Cell Carcinoma
This study analyzed tumor-associated inflammation by assessing the expression of cyclophilin A (CypA) and TNF in samples of kidney tumors of various...
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Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma
BackgroundRNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function in...
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PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
BackgroundSunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to its significant...
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MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression
BackgroundLipid droplet formation is a prominent histological feature in clear cell renal cell carcinoma (ccRCC), but the significance and mechanisms...
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Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma
In this retrospective study involving 112 patients with clear cell renal cell carcinoma (ccRCC), we analyzed clinical significance and prognostic...
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IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis
BackgroundClear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced...
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Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma
PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed...
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The microbiota and renal cell carcinoma
Renal cell carcinoma (RCC) accounts for about 2% of cancer diagnoses and deaths worldwide. Recent studies emphasized the critical involvement of...
