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Indicators of Immune and Neurohumoral Profile in Women of Fertile Age with Functional Disorders of the Autonomic Nervous System Associated with Polymorphic Variants of the HTR2A (rs7997012) and TP53 (rs1042522) Genes
In women of fertile age with functional disorders of the autonomic nervous system (ANS), a complex of indicators of the immune and neurohumoral...
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Relationship Between Genetic Polymorphisms in Cell Cycle Regulatory Gene TP53 and Polycystic Ovarian Syndrome: A Case–Control Study and In Silico Analyses
Polycystic ovarian syndrome (PCOS) is a complex endocrine and metabolic condition with several potential causes. Insulin resistance is a hallmark of...
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Association Between Genetic Variants in the lncRNA–p53 Regulatory Network and Ischemic Stroke Prognosis
Long noncoding RNAs (lncRNAs) serve as regulators or effectors of the p53 regulatory pathway. The lncRNA–p53 regulatory network plays an important...
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Association of Polymorphic Markers of the TP53, MDM2, and CDKN1A Genes with the Risk of Ovarian Cancer
AbstractThe distribution of allele frequencies of polymorphic markers of the genes of the apoptosis and cell cycle control system TP53 (rs1042522), MDM2...
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Prediction of esophageal cancer risk based on genetic variants and environmental risk factors in Chinese population
BackgroundResults regarding whether it is essential to incorporate genetic variants into risk prediction models for esophageal cancer (EC) are...
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Triple Haplotypes of the TP53 Gene in Patients with Diffuse Small B-Cell Lymphoma
AbstractThe role of genetic susceptibility to the development of lymphoma is confirmed by the accumulating data on common genetic variants of the...
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TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms. Mutations in the two Cushing’s disease mutational hotspots USP8 ...
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Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
BackgroundPreeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in...
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Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer
Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in...
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TP53 Polymorphism Contributes to the Susceptibility to Bipolar Disorder but Not to Schizophrenia in the Chinese Han Population
TP53 has been reported to be involved in diverse neurological processes related to the pathogenesis of psychosis. In this study, we aim to determine...
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Clinical and genetic characteristics of carriers of the TP53 c.541C > T, p.Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent
TP53 pathogenic variants cause Li-Fraumeni syndrome (LFS), with some variants causing an attenuated phenotype. Herein, we describe the clinical...
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Chromosomal Instability and Genetic Polymorphism in Miners and Workers of Coal Thermal Power Plants
AbstractPolymorphic variants of genes of enzymes of xenobiotic biotransformation ( CYP1A1 ( rs4646903 ), CYP1A2 ( rs762551 ), CYP2D6 ( rs35742686 ), CYP2E1 ...
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Integrated analysis identifies GABRB3 as a biomarker in prostate cancer
BackgroundTreatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate...
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Inherited alterations of TGF beta signaling components in Appalachian cervical cancers
PurposeThis study examined targeted genomic variants of transforming growth factor beta (TGFB) signaling in Appalachian women. Appalachian women with...
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Single nucleotide polymorphisms and the risk of develo** a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis
BackgroundHead and Neck Cancer (HNC) survivors are at increased risk of develo** a second primary cancer (SPC). Along with the environmental risk...
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Genetic susceptibility of bladder cancer in the Lebanese population
BackgroundBladder cancer (BC) is the 10 th most frequent tumor worldwide. Evidence shows an association between elevated risk of BC and various...
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Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study
BackgroundCervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important...
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Role of Genetic Polymorphisms in Breast Cancer
Of all cancers that affect women, the highest number of deaths results from breast cancer (BC). The tumorigenesis of BC is due to either chromosomal...
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DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics
BackgroundMature cystic teratomas of the ovary are the most common type of germ cell tumor, comprising 33% of ovarian tumors. Studying these tumors...
