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The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 contains HMG-box domain and...
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Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma...
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MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and chemotherapy are the...
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Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately...
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Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia
The cerebellum plays an important role in cognitive and social functioning. Childhood damage in the cerebellum increases the risk of autism spectrum...
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Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn’s disease patients
Thiopurines, an effective therapy for Crohn’s disease (CD), often lead to adverse events (AEs). Gene polymorphisms affecting thiopurine metabolism...
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Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either...
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Nimodipine-associated standard dose reductions and neurologic outcomes after aneurysmal subarachnoid hemorrhage: the era of pharmacogenomics
Nimodipine, an L-type cerebroselective calcium channel antagonist, is the only drug approved by the US Food and Drug Administration for the...
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Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice
Areca nut, the seed of Areca catechu L., is one of the most widely consumed addictive substances in the world after nicotine, ethanol, and caffeine....
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Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories
Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the...
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Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens
The potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in...
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Adolescent chemogenetic activation of dopaminergic neurons leads to reversible decreases in amphetamine-induced stereotypic behavior
Chronic perturbations of neuronal activity can evoke homeostatic and new setpoints for neurotransmission. Using chemogenetics to probe the...
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Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation
The brain responds to experience through modulation of synaptic transmission, that is synaptic plasticity. An increase in the strength of synaptic...
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Globus pallidus is not independent from striatal direct pathway neurons: an up-to-date review
Striatal projection neurons, which are classified into two groups—direct and indirect pathway neurons, play a pivotal role in our understanding of...
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Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice
Loss-of-function mutations in the progranulin ( GRN ) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically...
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TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in...
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Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous...
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Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects
The aim was to determine if opioid neuroimmunopharmacology pathway gene polymorphisms alter serum morphine, morphine-3-glucuronide and...
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APF2: an improved ensemble method for pharmacogenomic variant effect prediction
Lack of efficacy or adverse drug response are common phenomena in pharmacological therapy causing considerable morbidity and mortality. It is...
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Hypothalamic protein profiling from mice subjected to social defeat stress
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay center between the body...
