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Localized fine-tuning and clinical evaluation of deep-learning based auto-segmentation (DLAS) model for clinical target volume (CTV) and organs-at-risk (OAR) in rectal cancer radiotherapy
Background and purposeVarious deep learning auto-segmentation (DLAS) models have been proposed, some of which have been commercialized. However, the...
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Peer2Me – evaluation of a peer supported program for adolescent and young adult (AYA) cancer patients: study protocol of a randomised trial using a comprehensive cohort design
BackgroundDevelo** cancer in young adulthood is a non-normative life event and associated with adverse physical, social and psychological...
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Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis
The contribution of the human papillomavirus (HPV) to cancer is significant but not exclusive, as carcinogenesis involves complex mechanisms, notably...
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Climate change advocacy and cancer clinical trial organisations
BackgroundClimate change is a threat to human health; equally health care is a threat to climate change as it accounts for 4% of greenhouse gas...
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Effect of testosterone therapy on breast tissue composition and mammographic breast density in trans masculine individuals
BackgroundThe effect of gender-affirming testosterone therapy (TT) on breast cancer risk is unclear. This study investigated the association between...
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Serum miRNA-1 may serve as a promising noninvasive biomarker for predicting treatment response in breast cancer patients receiving neoadjuvant chemotherapy
BackgroundMicroRNA-1 (miR-1) is a tumour suppressor that can inhibit cell proliferation and invasion in several cancer types. In addition, miR-1 was...
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Rapid detection of lung cancer based on serum Raman spectroscopy and a support vector machine: a case-control study
BackgroundEarly screening and detection of lung cancer is essential for the diagnosis and prognosis of the disease. In this paper, we investigated...
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Exploring long-term cancer survivors’ care experiences and unmet needs: protocol for a qualitative study
BackgroundThe number of cancer survivors has increased in recent decades, and the majority of them suffer from sequelae of their disease and...
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Utilizing human cerebral organoids to model breast cancer brain metastasis in culture
BackgroundMetastasis, the spread, and growth of malignant cells at secondary sites within a patient’s body, accounts for over 90% of cancer-related...
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Breast cancer treatment and its impact on survival in Morocco: a study over a decade
BackgroundIn Morocco, much progress has been made in breast cancer treatment. However, there is limited information on survival outcomes of breast...
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A novel colorectal cancer test combining microsatellite instability and BRAF/RAS analysis: Clinical validation and impact on Lynch syndrome screening
BackgroundLynch syndrome (LS) is under-diagnosed. UK National Institute for Health and Care Excellence guidelines recommend multistep molecular...
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Enhancing circulatory myokines and extracellular vesicle uptake with targeted exercise in patients with prostate cancer (the MYEX trial): a single-group crossover study
IntroductionPhysical activity is associated with improved disease progression and cancer-specific survival in patients with prostate cancer (PCa)....
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LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
BackgroundLeukocyte Ig-like receptor B family 4 (LILRB4) as an immune checkpoint on myeloid cells is a potential target for tumor therapy. Extensive...
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Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial
BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a...
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Dermoscopic characteristics of Merkel cell carcinoma
BackgroundMerkel cell carcinoma (MCC) is a rare, aggressive, cutaneous tumour with high mortality and frequently delayed diagnosis. Clinically, it...
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Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy....
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Effect of cross-platform gene-expression, computational methods on breast cancer subty** in PALOMA-2 and PALLET studies
Intrinsic breast cancer molecular subty** (IBCMS) provides significant prognostic information for patients with breast cancer and helps determine...
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The association between systemic immune-inflammation index and cardiotoxicity related to 5-Fluorouracil in colorectal cancer
Background and aimsThe cardiotoxicity related to 5-Fluorouracil (5-FU) in cancer patients has garnered widespread attention. The systemic...
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Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately...
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Monitoring changing patterns in HER2 addiction by liquid biopsy in advanced breast cancer patients
BackgroundDuring targeted treatment, HER2-positive breast cancers invariably lose HER2 DNA amplification. In contrast, and interestingly, HER2...
