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Systematic Evaluation of Osimertinib Population Pharmacokinetic Models in a Cohort of Dutch Adults with Non-Small Cell Lung Cancer
Background and ObjectiveSeveral population pharmacokinetic (popPK) studies have been reported that can guide the prediction of osimertinib plasma...
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Inverted Alu repeats: friends or foes in the human transcriptome
Alu elements are highly abundant primate-specific short interspersed nuclear elements that account for ~10% of the human genome. Due to their...
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Big data and deep learning for RNA biology
The exponential growth of big data in RNA biology (RB) has led to the development of deep learning (DL) models that have driven crucial discoveries....
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Molecular mechanisms of circular RNA translation
Circular RNAs (circRNAs) are covalently closed single-stranded RNAs without a 5′ cap structure and a 3′ poly(A) tail typically present in linear...
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Elucidation of how the Mir-23-27-24 cluster regulates development and aging
MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the...
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Model-Based Bioequivalence Analysis to Assess and Predict the Relative Bioavailability of Valproic Acid Formulations
Background and ObjectiveModel-based bioequivalence (MBBE) encompasses the use of nonlinear mixed effect models supporting the estimation of...
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Optimal design of synthetic circular RNAs
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently linked via back-splicing. Due to their versatility, the need to...
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Molecular insights into regulatory RNAs in the cellular machinery
It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted...
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The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore...
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Neuron type-specific optogenetic stimulation for differential stroke recovery in chronic capsular infarct
Cortical neuromodulation (CNM) is widely used to promote recovery after stroke. Despite the beneficial results of CNM, the roles played by different...
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Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Interleukin-9 (IL-9) is a multifunctional cytokine with roles in a broad cross-section of human diseases. Like many cytokines, IL-9 is...
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Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark...
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Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway
The effects of ultraviolet (UV) radiation on brain function have previously been investigated; however, the specific neurotransmitter-mediated...
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The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism
N 6 -adenosine methylation (m 6 A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m
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IL-33 and IL-33-derived DC-based tumor immunotherapy
Interleukin-33 (IL-33), a member of the IL-1 family, is a cytokine released in response to tissue damage and is recognized as an alarmin. The...
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Regulation of metaplasia and dysplasia in the stomach by the stromal microenvironment
Research on the microenvironment associated with gastric carcinogenesis has focused on cancers of the stomach and often underestimates premalignant...
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RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide, and the identification of novel treatment targets and prognostic...
