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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
Behcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3...
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Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay
ObjectiveHIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Objective and designCompelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel...
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Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages
Liver X receptors (LXRs) which link lipid metabolism and inflammation, were overexpressed in experimental rheumatoid arthritis (RA) rats as observed...
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A systematic review of the drug-drug interaction between Statins and Quinolones
BackgroundStatins are widely used in cardiovascular disease (CVD) as a common lipid-lowering drug, while quinolones are widely used for the treatment...
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Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
BackgroundTourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics. It is a condition that affects between 0.3%...
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Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection
BackgroundMalaria is a life-threatening parasitic disease typically transmitted through the bite of an infected Anopheles mosquito. There is ample...
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Efficacy and safety of infliximab and adalimumab in inflammatory bowel disease patients
IntroductionInflammatory bowel disease (IBD), consists of two primary types: Ulcerative Colitis (UC) and Crohn’s Disease (CD). Infliximab (IFX) and...
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Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Sco** Review
Purpose of ReviewEnvironmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early...
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Revolutionizing Pharma: Prioritizing Industry 4.0 Implementation Challenges in the Indian Pharmaceutical Landscape Through Analytical Hierarchy Process Analysis
PurposeThe manufacturing industry is changing quickly because of trends like automation and high-volume customization. Industry 4.0 is a movement...
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Survey on Perkinsus species in two economic mussels (Mytilus coruscus and M. galloprovincialis) along the coast of the East China Sea and the Yellow Sea
Perkinsus , a parasitic pathogen of marine bivalves, is widely distributed among various mollusks in numerous countries. However, the prevalence and...
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Molecular characterizations of Cryptosporidium spp. in brown rat (Rattus norvegicus) from an animal feedlot in **njiang, China
Cryptosporidium infection is a common occurrence in rodents worldwide. In this study, 435 wild brown rats were captured from an animal feedlot in...
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The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies
Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor...
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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
