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Neurobehavioral, neurotransmitter and redox modifications in Nauphoeta cinerea under mixed heavy metal (silver and mercury) exposure
Heavy metals are encountered in nature, and are used in several human endeavors, including in dental fillings. It is well known that the safety of...
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Acute myeloid leukemia first presentation with central nervous system (CNS) involvement: a case report
BackgroundAcute myeloid leukemia (AML) typically presents with bone marrow myeloblast replacement, which can interfere with normal hematopoiesis. In...
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Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19
The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the...
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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition
BackgroundInhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment...
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An novel effective and safe model for the diagnosis of nonalcoholic fatty liver disease in China: gene excavations, clinical validations, and mechanism elucidation
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. NAFLD leads to liver fibrosis and...
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The clinical significance of inflammatory mediators in predicting obesity and progression-free survival in patients with adult-onset Craniopharyngioma
BackgroundCraniopharyngioma (CP) is a rare malformational tumor characterized by high rates of recurrence and morbid obesity. However, the role of...
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It’s about time: mitigating cancer-related cognitive impairments through findings from computational models of the Wisconsin Card Sorting Task
BackgroundMany cancer survivors experience cancer-related cognitive impairment (CRCI), often with significant negative consequences across various...
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Establishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to...
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Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
BackgroundObesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that...
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Atypical presentations in an RTD patient and report of novel SLC52A3 and SLC52A2 mutations
IntroductionRiboflavin Transporter Deficiency (RTD) is a rare neurological disorder characterized by pontobulbar palsy, hearing loss, and motor...
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KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors
BackgroundKallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and...
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Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers
BackgroundCarbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that is increased in heart failure (HF) and associated with...
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DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition
IntroductionIntrauterine adhesions (IUA) manifest as endometrial fibrosis, often causing infertility or recurrent miscarriage; however, their...
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HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease
We investigated the phenotypic characteristics of human leukocyte antigen (HLA)-E-expressing macrophages, NKG2A/CD94 expression in T and natural...
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Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis
ObjectiveTo explore the correlation between asthma risk and genetic variants affecting the expression or function of lipid-lowering drug targets.
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The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The mucosal origin hypothesis of rheumatoid arthritis has renewed the interest in IgA autoantibodies, but their added value over IgG...
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Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy
BackgroundThe tumor microenvironment is profoundly heterogeneous particularly when comparing sites of metastases. Establishing the extent of this...
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Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens
BackgroundCOVID-19 is primarily considered a respiratory tract infection, but it can also affect the central nervous system (CNS), which can result...
