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Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
BackgroundIncreasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Heat-related illness and dementia: a study integrating epidemiological and experimental evidence
BackgroundHeat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We...
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Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
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Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
BackgroundEnlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive...
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APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets
The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β (Aβ) peptides are generated after proteolytic cleavage. Aβ...
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Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
BackgroundPosttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as...
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Comparison of plasma soluble and extracellular vesicles-associated biomarkers in Alzheimer’s disease patients and cognitively normal individuals
BackgroundAmyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD), also present in blood as soluble biomarkers or encapsulated in...
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The criteria used to rule out mild cognitive impairment impact dementia incidence rates in subjective cognitive decline
BackgroundThe research criteria for subjective cognitive decline (SCD) exclude mild cognitive impairment (MCI), but do not stipulate the use of...
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Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19
BackgroundAlthough it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the...
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The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
BackgroundNon-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cognitive function...
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Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study
BackgroundLiver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations...
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Association between depression and young-onset dementia in middle-aged women
BackgroundDementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when...
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Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated...
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The longitudinal trajectory of CSF sTREM2: the alzheimer’s disease neuroimaging initiative
BackgroundThe soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) is considered a biomarker of microglia...
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Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
BackgroundAlthough several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known...
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Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease
BackgroundRecently developed blood markers for Alzheimer's disease (AD) detection have high accuracy but usually require ultra-sensitive analytic...
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Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
BackgroundNeutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity remains poorly...
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Adherence to a lifestyle intervention – just a question of self-efficacy? Analysis of the AgeWell.de-intervention against cognitive decline
BackgroundAim of this study was to detect predictors of better adherence to the AgeWell.de-intervention, a two-year randomized multi-domain lifestyle...
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Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a...
