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ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors
PurposePARP inhibitors (PARPi) are effective in homologous recombination repair (HRR) defective (HRD) cancers. To (re)sensitise HRR proficient (HRP)...
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Efficacy of a nurse-led sexual rehabilitation intervention for women with gynaecological cancers receiving radiotherapy: results of a randomised trial
BackgroundThe multicentre randomised SPARC trial evaluated the efficacy of a nurse-led sexual rehabilitation intervention on sexual functioning,...
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DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance
BackgroundCurrent risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing...
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Challenges in collecting information on sexual orientation and gender identity for cancer patients: perspectives of hospital and central cancer registry abstractors
PurposeSexual and gender minority (SGM) populations experience cancer treatment and survival disparities; however, inconsistent sexual orientation...
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ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles
BackgroundEsophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically ideal biomarkers for early diagnosis. The objective of this...
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Transmission dynamics of avian influenza viruses in Egyptian poultry markets
Live bird markets (LBMs) are considered hotspots for Avian Influenza Viruses (AIVs). In such markets, AIVs pose threats to both poultry and public...
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Digital innovation for cancer risk assessment allows large-scale service redevelopment of regional cancer genetics service delivery
Family-history assessment can identify individuals above population-risk for cancer to enable targeted Screening, Prevention and Early Detection...
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Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial
BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a...
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KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer
BackgroundDNMT3A is a crucial epigenetic regulation enzyme. However, due to its heterogeneous nature and frequent mutation in various cancers, the...
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Cancer risk in individuals with polydactyly: a Swedish population-based cohort study
BackgroundPolydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polydactyly is largely...
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Cancer fatalism, social media informational awareness, and education
ObjectiveUnderstand if cancer fatalism among adult social media users in the United States is linked to social media informational awareness and if...
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Exposure to second-hand smoke and breast cancer risk in non-smoking women: a comprehensive systematic review and meta-analysis
Through the use of an innovative method to identify original publications, we conducted a meta-analysis of all epidemiological studies evaluating the...
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Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours
BackgroundCertain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and...
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A population-based study on trajectories of HER2 status during neoadjuvant chemotherapy for early breast cancer and metastatic progression
BackgroundThis study aimed to investigate the distribution and changes of HER2 status in untreated tumours, in residual disease and in metastasis,...
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Prognostic significance of PET/CT and its association with immuno-genomic profiling in oesophageal squamous cell carcinoma treated with immunotherapy plus chemoradiotherapy: results from a phase II study
BackgroundA phase II trial (EC-CRT-001) demonstrated the promising efficacy of combining toripalimab (an anti-PD-1 antibody) with definitive...
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The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities
BackgroundWe proposed the Physical Activity and Cancer Control (PACC) framework in 2007 to help organise, focus, and stimulate research on physical...
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Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
BackgroundPancreatoduodenectomy is the only cure for cancers of the pancreas and the periampullary region but has considerable operative...
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Efficacy of administration sequence: Sacituzumab Govitecan and Trastuzumab Deruxtecan in HER2-low metastatic breast cancer
BackgroundCurrent guidelines recommend that patients with HER2-low metastatic breast cancer (MBC) receive sequentially two antibody–drug conjugates...
