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Twenty-five years of surveillance for familial and hereditary pancreatic ductal adenocarcinoma: Historical perspectives and introduction to the special issue
In the 1990s, as prevention became a central strategy in the battle against cancer and the molecular genetics revolution uncovered the genetic basis...
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Association between inflammatory factors and melanoma: a bidirectional Mendelian randomization study
PurposeThis study performed a bidirectional Mendelian randomization (MR) analysis to elucidate the causal relationships of C-reactive protein and 41...
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A nationwide study of breast reconstruction after mastectomy in patients with breast cancer receiving postmastectomy radiotherapy: comparison of complications according to radiotherapy fractionation and reconstruction procedures
BackgroundWe examined the patterns of breast reconstruction postmastectomy in breast cancer patients undergoing postmastectomy radiotherapy (PMRT)...
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Gastrointestinal stromal tumour (GIST): British Sarcoma Group clinical practice guidelines
BackgroundBritish Sarcoma Group guidelines for the management of GIST were initially informed by those published by the European Society of Clinical...
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Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
BackgroundTolerability and antitumour efficacy of chemotherapy and radiation therapy can vary largely according to their time of administration along...
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CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas
BackgroundDiffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular driver(s) of pHGG...
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Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer
BackgroundPreoperative chemoradiotherapy (CRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). We reported...
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Joint ABS-UKCGG-CanGene-CanVar consensus regarding the use of CanRisk in clinical practice
BackgroundThe CanRisk tool, which operationalises the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is...
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Clinical landscape of macrophage-reprogramming cancer immunotherapies
Tumour-associated macrophages (TAMs) sustain a tumour-supporting and immunosuppressive milieu and therefore aggravate cancer prognosis. To modify TAM...
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Identifying patients with undiagnosed small intestinal neuroendocrine tumours in primary care using statistical and machine learning: model development and validation study
BackgroundNeuroendocrine tumours (NETs) are increasing in incidence, often diagnosed at advanced stages, and individuals may experience years of...
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Tracing household transmission of SARS-CoV-2 in New Zealand using genomics
By early 2022, the highly transmissible Omicron variant of SARS-CoV-2 had spread across most of the world. For the first time since the pandemic...
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Somatic STK11 mosaicism in a Turkish patient with Peutz-Jeghers syndrome
Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder, caused by germline variants in the serine/threonine kinase 11 ( STK11 ) gene. However,...
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DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity
BackgroundDisorder of cell cycle represents as a major driver of hepatocarcinogenesis and constitutes an attractive therapeutic target. However,...
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Attitudes toward genetic testing, family planning and preimplantation genetic testing in families with a germline CDKN2A pathogenic variant
Individuals with a germline CDKN2A pathogenic variant (PV) have a highly increased life time risk of melanoma and pancreatic cancer. This...
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Prevalence of congenital anomalies and prenatal diagnosis by birth institution (public vs. non-public): indicators of inequality in access to elective termination of pregnancy for fetal anomalies
Congenital anomalies (CA) encompass all morphological or functional alterations originating prenatally and present at birth. The prenatal diagnosis...
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A retrospective cohort study of genetic referral and diagnosis of Birt-Hogg-Dubé Syndrome in patients with Trichodiscoma and Fibrofolliculoma skin lesions
BackgroundBirt-Hogg-Dubé (BHD) syndrome is a genetic condition caused by pathogenic variants in the FLCN gene resulting in benign skin lesions,...
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The effect of mailed outreach on FIT completion among patients aged 45–50 in a safety net healthcare system
PurposeColorectal cancer screening is recommended starting at age 45, but there has been little research on strategies to promote screening in...
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Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer
BackgroundRecent therapeutic strategies for KRAS-mutated cancers that inhibit the MAPK pathway have attracted considerable attention. The RAF/MEK...
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PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
BackgroundSunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to its significant...
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Family communication of cancer genetic test results in an ethnically diverse population: a qualitative exploration of more than 200 patients
Previous research on family communication of cancer genetic test results has primarily focused on non-Hispanic White patients with high-risk...