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DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance
BackgroundCurrent risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing...
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A unified metric of human immune health
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some...
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Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators
Hibernation allows mammals to endure harsh seasons by reducing their basal metabolism and body temperature (Tb) to minimize energy expenditure....
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Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development
Circadian disruption, as a result of shiftwork, jet lag, and other lifestyle factors, is a common public health problem associated with a wide range...
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The role of BCAA metabolism in metabolic health and disease
It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans....
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Challenges in collecting information on sexual orientation and gender identity for cancer patients: perspectives of hospital and central cancer registry abstractors
PurposeSexual and gender minority (SGM) populations experience cancer treatment and survival disparities; however, inconsistent sexual orientation...
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Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel
Piezo1 mechanosensitive ion channel plays a important role in vascular physiology and disease. This study aimed to elucidate the altered signaling...
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ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles
BackgroundEsophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically ideal biomarkers for early diagnosis. The objective of this...
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Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Preclinical evidence demonstrates that senescent cells accumulate with aging and that senolytics delay multiple age-related morbidities, including...
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Benefits for children with suspected cancer from routine whole-genome sequencing
Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk...
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Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous...
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SARS-CoV-2-related peptides induce endothelial-to-mesenchymal transition in endothelial capillary cells derived from different body districts: focus on membrane (M) protein
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV‐2), responsible for the COVID-19, may lead to multiple organ dysfunctions and long-term...
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The heterogeneity of erythroid cells: insight at the single-cell transcriptome level
Erythroid cells, the most prevalent cell type in blood, are one of the earliest products and permeate through the entire process of hematopoietic...
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Healthcare system resilience and adaptability to pandemic disruptions in the United States
Understanding healthcare system resilience has become paramount, particularly in the wake of the COVID-19 pandemic, which imposed unprecedented...
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Transmission dynamics of avian influenza viruses in Egyptian poultry markets
Live bird markets (LBMs) are considered hotspots for Avian Influenza Viruses (AIVs). In such markets, AIVs pose threats to both poultry and public...
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Combined effect of naringin and adipose tissue-derived mesenchymal stem cell on cisplatin nephrotoxicity through Sirtuin1/Nrf-2/HO-1 signaling pathway: a promising nephroprotective candidate
Cisplatin nephrotoxicity is a well-known emergency clinical condition caused by oxidative stress and inflammation. Naringin (NAR) is considered an...
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Gene Therapies in Clinical Development to Treat Retinal Disorders
Gene therapies have emerged as promising treatments in clinical development for various retinal disorders, offering hope to patients with inherited...
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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy (DE) is a serious...
