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The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients
BackgroundStroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in...
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A new approach to prevent radiation-induced xerostomia using intraglandular injection of mitochondria-boosting agents
Radiotherapy in patients with head and neck cancer fairly leads to xerostomia, profoundly affecting their quality of life. With limited effective...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems
Paclitaxel, a potent chemotherapeutic agent derived from the bark of the Pacific yew tree, has demonstrated significant efficacy in the treatment of...
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Circ_0000069 promotes the development of hepatocellular carcinoma by regulating CCL25
BackgroundHepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, influenced by aberrant circRNA expression....
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Heterogeneity in choice models of addiction: the role of context
RationaleTheories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how people experiencing or...
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Precision public health in the era of genomics and big data
Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and...
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Understanding the experience, treatment preferences and goals of people living with chronic lymphocytic leukemia (CLL) in Australia
BackgroundListening to patient voices is critical, in terms of how people experience their condition as well as their treatment preferences. This...
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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of...
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Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments
As one of the significant challenges to human health, cancer has long been a focal point in medical treatment. With ongoing advancements in the field...
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Evaluation of the Protective Effects of Lugol’s Solution in Rats Poisoned with Aluminum Phosphide (Rice Tablets)
Aluminum phosphide (AlP) is the main component of rice tablets (a pesticide), which produces phosphine gas (PH3) when exposed to stomach acid. The...
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Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer
BackgroundTreatment with regorafenib, a multiple-kinase inhibitor, to manage metastatic colorectal cancers (mCRCs) shows a modest improvement in...
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Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats
Brain microvascular endothelial cells (BMECs), an important component of the neurovascular unit, can promote angiogenesis and synaptic formation in...
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously
BackgroundMacrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the...
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Celecoxib inhibits NLRP1 inflammasome pathway in MDA-MB-231 Cells
NLRP1 is predominantly overexpressed in breast cancer tissue, and the evaluated activation of NLRP1 inflammasome is associated with tumor growth,...
