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Acute myeloid leukemia first presentation with central nervous system (CNS) involvement: a case report
BackgroundAcute myeloid leukemia (AML) typically presents with bone marrow myeloblast replacement, which can interfere with normal hematopoiesis. In...
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Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially results in life-threatening...
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Characteristics of the Antitumor Effect of Doxorubicin and Pegylated Hyaluronidase on Models of Rat Brain Tumors
Hyaluronidase increases tissue permeability and diffusion of the extracellular fluid by cleaving hyaluronan, the primary component of the...
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TGFβ1 Regulates Cellular Composition of In Vitro Cardiac Perivascular Niche Based on Cardiospheres
The cardiac perivascular niche is a cellular microenvironment of a blood vessel. The principles of niche regulation are still poorly understood. We...
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Evaluation and mitigation of the limitations of large language models in clinical decision-making
Clinical decision-making is one of the most impactful parts of a physician’s responsibilities and stands to benefit greatly from artificial...
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Harnessing EHR data for health research
With the increasing availability of rich, longitudinal, real-world clinical data recorded in electronic health records (EHRs) for millions of...
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Analysis of the Diversity and Functional Potential of Bacterial Communities in Tuberculomas
The dynamics of lung microbiota in tuberculosis remains poorly understood. Sequencing of variable regions of the 16S rRNA gene from surgically...
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Morphometric Indicators of Liver Acini of Deceased Newborns Depending on the Time of Death
We studied morphometric changes in the liver acini of dead newborns depending on the duration of the postmortem period. Autopsy samples of the liver...
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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Genetic heterogeneity and co-occurring driver mutations impact clinical outcomes in blood cancers, but predicting the emergent effect of co-occurring...
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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition
BackgroundInhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment...
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An novel effective and safe model for the diagnosis of nonalcoholic fatty liver disease in China: gene excavations, clinical validations, and mechanism elucidation
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. NAFLD leads to liver fibrosis and...
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Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19
The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the...
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Comparative Morphological and Molecular Genetic Characteristics of Cell and Tissue Strains of Experimental Rat Glioma 10-17-2 (Astrid-17)
In order to obtain models of gliomas of varying degrees of malignancy, we performed morphological and molecular genetic study of a tissue strain of...
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Correlation between the Colony Phenotype and Amino Acid Sequence of the Variable Vaa Antigen in Clinical Isolates of Mycoplasma hominis
A new Mycoplasma hominis phenotype forming mini-colonies (MC) on agar and distinct from the phenotype forming typical colonies (TC) not only in size,...
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Effect of Short Peptides of Pregnancy-Specific β1-Glycoprotein on Differentiation of Human Regulatory T Cells In Vitro and on Their Cytokine Profile
Pregnancy-specific β1-glycoprotein (PSG), one of the most important proteins of pregnancy, has a pronounced immunosuppressive effect. Short peptides...
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New Aspects in the Study of Lactobacillus iners
A cultural microbiological study of the vaginal microbiota of patients of reproductive age was carried out to isolate the species Lactobacillus iners ...
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It’s about time: mitigating cancer-related cognitive impairments through findings from computational models of the Wisconsin Card Sorting Task
BackgroundMany cancer survivors experience cancer-related cognitive impairment (CRCI), often with significant negative consequences across various...
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Multiple myeloma: signaling pathways and targeted therapy
Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells, characterized by osteolytic bone lesions, anemia,...
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Experimental Modeling of Cranial Injury and Defect Reconstruction Using Superconstructive Polymers (PEEK)
Experimental model of resection craniotomy with subsequent reconstruction of the defect with a polymer implant enables comprehensive assessment of...