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The role of hydrogen sulfide regulation of ferroptosis in different diseases
Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as...
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Two-Stage Classification of Future Knee Osteoarthritis Severity After 8 Years Using MRI: Data from the Osteoarthritis Initiative
Currently, there are no methods or tools available in clinical practice for classifying future knee osteoarthritis (KOA). In this study, we aimed to...
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Metabolomic and lipidomic profiling of the spinal cord in type 2 diabetes mellitus rats with painful neuropathy
In this paper we investigated lipid and metabolite changes in diabetic neuropathy, using untargeted lipidomics and metabolomics analyses of the...
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Pharmacokinetics and Histotoxic Profile of a Novel Azithromycin-Loaded Lipid-Based Nanoformulation
Azithromycin traditional formulations possesses poor oral bioavailability which necessitates development of new formulation with enhanced...
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Distribution Clearance: Significance and Underlying Mechanisms
PurposeEvaluation of distribution kinetics is a neglected aspect of pharmacokinetics. This study examines the utility of the model-independent...
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Formulation and Antimycotic Evaluation of Colloidal Itraconazole-Loaded Metered Dose Sprays for Treating Superficial Mycoses
Commercial topical formulations containing itraconazole (poorly water soluble), for mycotic infections, have poor penetration to infection sites...
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Development of a Novel Soft Tissue Measurement Device for Individualized Finite Element Modeling in Custom-Fit CPAP Mask Evaluation
PurposeIndividual facial soft tissue properties are necessary for creating individualized finite element (FE) models to evaluate medical devices such...
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Design, Characterization and Biopharmaceutical Applications of Novel Green Boron-Carbon Quantum Dots for Quantification of Apalutamide; Greenness Evaluations
The diagnosis of prostate cancer has been evolving in the current decade, with expected mortality rates of 499,000 death by the year 2030....
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Fitness costs of Tn1546-type transposons harboring the vanA operon by plasmid type and structural diversity in Enterococcus faecium
BackgroundThis study analyzed the genetic traits and fitness costs of vancomycin-resistant Enterococcus faecium (VREfm) blood isolates carrying Tn 1546...
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Synthesis and anti-leishmanial activities of uniflorol analogues
Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and synthetic derivatives....
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Controlling Alzheimer’s disease by deep brain stimulation based on a data-driven cortical network model
This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven...
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the...
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Association of Sport Helmet Status on Concussion Presentation and Recovery in Male Collegiate Student-Athletes
Sporting helmets contain force attenuating materials which reduce traumatic head injury risk and may influence sport-related concussion (SRC)...
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A Comprehensive Literature Review on Advancements and Challenges in 3D Bioprinting of Human Organs: Ear, Skin, and Bone
The field of 3D bioprinting is rapidly emerging within the realm of regenerative medicine, offering significant potential in dealing with the issue...
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Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Local translation in growth cones plays a critical role in responses to extracellular stimuli, such as axon guidance cues. We previously showed that...
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Evaluation of the Transfemoral Bone–Implant Interface Properties Using Vibration Analysis
Evaluating the bone–implant interface (BII) properties of osseointegrated transfemoral (TFA) implants is important for early failure detection and...
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AI Shaming: The Silent Stigma among Academic Writers and Researchers
AI shaming refers to the practice of criticizing or looking down on individuals or organizations for using AI to generate content or perform tasks....
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Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan carboxamide and Schiff base derivatives were evaluated for their hypolipidemic activity. Fourteen derivatives were synthesised:...
