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Regeneration of Articular Cartilage
Loss of articular cartilage from the ends of bones forming diarthrodial joints can be the source of profound pain and disability, and eventually lead...
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Tissue Engineering Strategies for Bone Regeneration
Bone loss due to trauma or disease is an increasingly serious health problem. Current clinical treatments for critical-sized defects are problematic...
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Regeneration of Urologic Tissues and Organs
Patients suffering from a variety of urologic diseases may be treated with transplanted tissues and organs. However, there is a shortage of donor...
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Heart Valve Regeneration
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the...
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Simultaneous In Vivo Regeneration of Neodermis, Epidermis, and Basement Membrane
Full-thickness skin loss does not undergo complete spontaneous regeneration in mammals. To restore the normal function of skin, dermal and epidermal...
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Spinal Cord Regeneration
Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other achievements in neuroscience would have such a tremendous...
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Peripheral Nerve Regeneration
The nerve chamber model has dominated the experimental study of peripheral nerve (PN) regeneration with animal models as well as in several clinical...
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Mesomelia-synostoses syndrome: contiguous deletion syndrome, SULF1 haploinsufficiency or enhancer adoption?
BackgroundMesomelia-Synostoses Syndrome (MSS)(OMIM 600,383) is a rare autosomal dominant disorder characterized by mesomelic limb shortening, acral...
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Duo photoprotective effect via silica-coated zinc oxide nanoparticles and Vitamin C nanovesicles composites
ObjectiveZinc Oxide nanoparticles (ZnO NPs) are used widely in nowadays personal care products, especially sunscreens, as a protector against UV...
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Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
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Identification of a novel member of the genus Laulavirus (family Phenuiviridae) from the entomopathogenic ascomycete fungus Cordyceps javanica
The virus family Phenuiviridae (order Hareavirales , comprising segmented negative-sense single stranded RNA viruses) has highly diverse members that...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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Kinetic Modeling for BT200 to Predict the Level of Plasma-Derived Coagulation Factor VIII in Humans
Lack of Factor VIII (FVIII) concentrates is one of limiting factors for Hemophilia A prophylaxis in resource-limited countries. Rondaptivon pegol...
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Neutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic....
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HSPiP, Computational, and Thermodynamic Model–Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus‑Based In Vivo Prediction in Humans: Part II
In part I, we reported Hansen solubility parameters (HSP, HSPiP program), experimental solubility at varied temperatures for TOTA delivery. Here, we...
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Nanosuspension-Based Repaglinide Fast-Dissolving Buccal Film for Dissolution Enhancement
Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate...
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Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma...
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First detection and a new avian host of the tick Ixodes ventalloi Gil Collado, 1936, in Slovakia
This study describes the first detection of Ixodes ventalloi in Slovakia. Two engorged females of I. ventalloi were collected from Dunnocks ( Prunella...
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A wingless fly on a winged mammal: host-parasite dynamics between Basilia travassosi (Diptera: Nycteribiidae) and Myotis lavali (Chiroptera: Vespertilionidae)
Nycteribiidae encompasses a specialized group of wingless blood-sucking flies that parasitize bats worldwide. Such relationships are frequently...
