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Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
BackgroundThe accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a...
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Neutrophil–macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome
Cytokine storm syndrome (CSS) is a life-threatening systemic inflammatory syndrome involving innate immune hyperactivity triggered by various...
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Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively
Eomesodermin (Eomes) is a critical factor in the development of natural killer (NK) cells, but its precise role in temporal and spatial coordination...
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GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3
The NLRP3 inflammasome functions as an inflammatory driver, but its relationship with lipid metabolic changes in early sepsis remains unclear. Here,...
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Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
BackgroundQuercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative,...
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Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease
Peptidyl arginine deiminase 4 (PAD4) plays a pivotal role in infection and inflammatory diseases by facilitating the formation of neutrophil...
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Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
BackgroundAgeing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a...
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Emerging Innate Immune Cells in Cancer Immunotherapy: Promises and Challenges
Immune checkpoint inhibitor (ICI)-based therapy has made an unprecedented impact on survival benefit for a subset of cancer patients; however, only a...
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Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an...
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Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
BackgroundAtherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid...
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Immunopeptidome mining reveals a novel ERS-induced target in T1D
Autoreactive CD8 + T cells play a key role in type 1 diabetes (T1D), but the antigen spectrum that activates autoreactive CD8 + T cells remains...
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The effect of T cell aging on the change of human tissue structure
The trend of aging of the global population is becoming more and more significant, and the incidence of age-related diseases continues to rise.This...
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Tissue-specific features of innate lymphoid cells in antiviral defense
Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s,...
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Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its...
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HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status
BackgroundBipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals’...
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Impact of Early Access Reform on Oncology Innovation in France: Approvals, Patients, and Costs
BackgroundAn ambitious reform of the early access (EA) process was set up in July 2021 in France, aiming to simplify procedures and accelerate access...
