Search
Search Results
-
Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation
The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (IBD). Disruption of...
-
Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a...
-
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan
BackgroundThe magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disease 2019...
-
SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8
Type I interferon (IFN-I) exhibits broad-spectrum antiviral properties and is commonly employed in clinical for the treatment of viral infections. In...
-
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
BackgroundAge > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease,...
-
Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export
Myeloid-derived suppressor cells (MDSCs) are a main driver of immunosuppression in tumors. Understanding the mechanisms that determine the...
-
Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome
Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of...
-
Demonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Background and ObjectiveTocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800...
-
Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
An essential regulatory hub for retroviral replication events, the 5’ untranslated region (UTR) encodes an ensemble of cis-acting replication...
-
Barriers and Enablers Affecting the Uptake of Biosimilar Medicines Viewed Through the Lens of Actor Network Theory: A Systematic Review
Background and ObjectiveBiosimilars represent an opportunity to realise savings against the costs of innovative medicines. Despite efforts made by...
-
Postmarketing Reports of Incomplete Dosing-Related Complications with Self-Injected PCSK9 Inhibitors: A Descriptive Study and Disproportionality Analysis
BackgroundEvolocumab and alirocumab are self-injected proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors indicated for low-density...
-
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation,...
-
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis involves an immune response...
-
Immune cell phenotypes and mortality in the Framingham Heart Study
BackgroundGlobal life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable...
-
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Background and purposeThe immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD)....
-
Charting the Etanercept Journey: Tracing Cost Dynamics in Poland’s Off-Patent Market from Reference Drug Rivalry to Biosimilar Monopoly
ObjectivesTo evaluate the pricing of etanercept (ETN) reference and biosimilar drugs in a changing competitive to monopolized market.
...
-
Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the underlying mechanism...
-
Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
BackgroundStreptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust...
-
The role of blood related inflammatory factors on age-related macular degeneration (AMD)
BackgroundAge-related macular degeneration (AMD) is a significant retinal disease that leads to irreversible low vision, particularly in develo**...
-
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
Acute systemic inflammation critically alters the function of the immune system, often promoting myelopoiesis at the expense of lymphopoiesis. In the...
