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The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus
RationalePreclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies...
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Decoding the Preparation Stage of Target Shooting under Audiovisual Restricted Conditions: Investigating Neural Mechanisms Using Microstate Analysis
Shooting is a fine sport that is greatly influenced by mental state, and the neural activity of brain in the preparation stage of shooting has a...
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Heterogeneity in choice models of addiction: the role of context
RationaleTheories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how people experiencing or...
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Menstrual variations of sleep–wake rhythms in healthy women
The ovarian steroid hormones, estrogen and progesterone, the levels of which fluctuate dynamically with the estrous cycle, alter circadian behavioral...
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Investigation of macro and micro sleep structures of first night effect in school-aged children
This study aimed to investigate the occurrence and age-related changes of the first night effect (FNE) in school-age children using both macro (sleep...
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The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies
RationaleSelective serotonin reuptake inhibitors (SSRIs) are the first choice of treatment for anxiety-like disorders. However, which aspects of...
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Lemborexant as a Potential Risk Factor for Sleep-Related Bruxism in a Patient with Complex Post-traumatic Stress Disorder: A Case Report
This article describes a case involving a 21-year-old woman with complex post-traumatic stress disorder (C-PTSD) who developed sleep-related bruxism...
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Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study
BackgroundParkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular...
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Update on cannabis in human sexuality
RationaleSexuality is a central aspect of being human that encompasses many facets. Cannabis, a widely used psychoactive substance, has been...
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Simulated complexes formed from a set of postsynaptic proteins suggest a localised effect of a hypomorphic Shank mutation
BackgroundThe postsynaptic density is an elaborate protein network beneath the postsynaptic membrane involved in the molecular processes underlying...
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Obstructive Sleep Apnea: Relationship Between Mild Neurocognitive Impairments and Quality of Life
Patients with obstructive sleep apnea might have neurocognitive impairments and reduced quality of life. Considering the same, this study was...
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Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
RationaleNo previous studies examined the discriminative stimulus effects of intravenous (IV) nicotine in humans.
ObjectivesTo evaluate a pulsed IV...
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An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure
BackgroundA sizeable proportion of pathogenic genetic variants identified in young children tested for congenital differences are associated with...
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Reinforcing effects of fentanyl analogs found in illicit drug markets
RationaleThe potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is...
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Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
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Nucleus accumbens ghrelin signaling controls anxiety-like behavioral response to acute stress
BackgroundAnxiety disorders are one of the most common mental disorders. Ghrelin is a critical orexigenic brain-gut peptide that regulates food...
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Changes of brain functional network in Alzheimer’s disease and frontotemporal dementia: a graph-theoretic analysis
BackgroundAlzheimer’s disease (AD) and frontotemporal dementia (FTD) are the two most common neurodegenerative dementias, presenting with similar...
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Persistent vocal learning in an aging open-ended learner reflected in neural FoxP2 expression
BackgroundMost vocal learning species exhibit an early critical period during which their vocal control neural circuitry facilitates the acquisition...
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Cortical Generators and Connections Underlying Phoneme Perception: A Mismatch Negativity and P300 Investigation
The cortical generators of the pure tone MMN and P300 have been thoroughly studied. Their nature and interaction with respect to phoneme perception,...
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Developmental change of brain volume in Rett syndrome in Taiwan
ObjectiveRett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume...
