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The common bisulfite-conversion-based techniques to analyze DNA methylation in human cancers
DNA methylation is an important molecular modification that plays a key role in the expression of cancer genes. Evaluation of epigenetic changes,...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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EMBER creates a unified space for independent breast cancer transcriptomic datasets enabling precision oncology
Transcriptomics has revolutionized biomedical research and refined breast cancer subty** and diagnostics. However, wider use in clinical practice...
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Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain
Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this...
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N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is...
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Resveratrol Modulates Diabetes-Induced Neuropathic Pain, Apoptosis, and Oxidative Neurotoxicity in Mice Through TRPV4 Channel Inhibition
Diabetic peripheral neuropathy (DPN) is caused by several factors, including reactive free oxygen radicals (ROS)-induced excessive Ca 2+ influx....
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Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly
Protein phosphatase 2A (PP2A) is an abundant heterotrimeric holoenzyme in eukaryotic cells coordinating with specific kinases to regulate...
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DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration
Neurodegenerative diseases have a complex origin and are composed of genetic and environmental factors. Both DNA damage and chromatin rearrangement...
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Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory impairment and cognitive dysfunctions. It has been shown...
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Gut microbiota regulation of T lymphocyte subsets during systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of pro-inflammatory and anti-inflammatory...
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Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease all over the world. In the last decade, accumulating proofs have evidenced that...
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Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species
BackgroundDespite technological advances in radiotherapy, cancer cells at the tumor margin and in diffusive infiltrates can receive subcytotoxic...
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LCP1 correlates with immune infiltration: a prognostic marker for triple-negative breast cancer
ObjectiveTriple-Negative Breast Cancer (TNBC) is known for its aggressiveness and treatment challenges due to the absence of ER, PR, and HER2...
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Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Local translation in growth cones plays a critical role in responses to extracellular stimuli, such as axon guidance cues. We previously showed that...
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USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific...
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Administration and detection of a multi-target rAAV gene do** vector in horses using multiple matrices and molecular techniques
Gene do**, which includes the non-therapeutic use of genes or genetic elements that have the capacity to enhance athletic performance, is...
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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Integrating brain function and structure in the study of the human attentional networks: a functionnectome study
Attention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has...
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Association of HLA-G 3′UTR polymorphisms with hepatitis B virus infection in Tunisian population
Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly...
